应用 NCI 工具评估伊拉克女性乳腺癌发病风险。
Assessment of the Risk of Breast Cancer Development Applying NCI Tool among Iraqi Women.
机构信息
College of Science, University of Babylon, Iraq.
Deptment of Chemistry, Faculty of Education for Girls, University of Kufa, Iraq.
出版信息
Asian Pac J Cancer Prev. 2021 Oct 1;22(10):3121-3126. doi: 10.31557/APJCP.2021.22.10.3121.
OBJECTIVE
As part of the bioinformatics studies, we utilized National Cancer Institute (NCI)'s Breast Cancer Risk Assessment Tool to estimate the five-year period and lifetime risk of breast cancer development among Iraqi risky women.
METHODS
Totally, 110 risky women aged 21-67 (mean=36±7.4) years were interviewed by a series of questions regarding the risk of breast cancer development. Moreover, 100 cases with mutation in the BRCA1 or BRCA2 genes were included.
RESULTS
Our results demonstrated that the patient's estimated risk of breast cancer development during the next five years and lifetime (until the age 90 years) included 0.96% (p=0.211) and 9.97% (p=0.002), respectively being relatively low. Accordingly, the lifetime risk for the breast cancer development was significantly higher (10.38%) than that of 5-year. However, the age of patients was not significantly associated to the breast cancer development as there was no significant difference among various age groups.
CONCLUSION
It was concluded that long-term or lifetime period plays as a significant risk factor for developing breast cancer among female patients who had had a screening episode in Iraq.
目的
作为生物信息学研究的一部分，我们利用美国国立癌症研究所（NCI）的乳腺癌风险评估工具，估计伊拉克高危女性在五年内和一生中乳腺癌发展的风险。
方法
共对 110 名年龄在 21-67 岁（平均 36±7.4 岁）的高危女性进行了一系列关于乳腺癌发展风险的问题访谈。此外，还纳入了 100 例 BRCA1 或 BRCA2 基因突变的病例。
结果
我们的结果表明，患者未来五年和一生中（直至 90 岁）的乳腺癌发病估计风险分别为 0.96%（p=0.211）和 9.97%（p=0.002），相对较低。因此，乳腺癌的终生发病风险（10.38%）明显高于五年期。然而，患者的年龄与乳腺癌的发病无关，因为各年龄组之间没有显著差异。
结论
在伊拉克进行过筛查的女性患者中，长期或终生时间是乳腺癌发生的一个显著危险因素。
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