Wintermark Pia, Mohammad Khorshid, Bonifacio Sonia L
Department of Pediatrics, Division of Newborn Medicine, Montreal Children's Hospital, McGill University, Montreal, QC, Canada.
Department of Pediatrics, Section of Neonatology, University of Calgary, 28 Oki Drive NW, T3B 6A8, Calgary, AB, Canada.
Semin Fetal Neonatal Med. 2021 Oct;26(5):101303. doi: 10.1016/j.siny.2021.101303. Epub 2021 Oct 16.
Neonates with neonatal encephalopathy (NE) often present with multi-organ dysfunction that requires multidisciplinary specialized management. Care of the neonate with NE is thus complex with interaction between the brain and various organ systems. Illness severity during the first days of birth, and not only during the initial hypoxia-ischemia event, is a significant predictor of adverse outcomes in neonates with NE treated with therapeutic hypothermia (TH). We thus propose a care practice bundle dedicated to support the injured neonatal brain that is based on the current best evidence for each organ system. The impact of using such bundle on outcomes in NE remains to be demonstrated.
患有新生儿脑病（NE）的新生儿常出现多器官功能障碍，需要多学科的专业管理。因此，患有NE的新生儿的护理很复杂，涉及大脑与各种器官系统之间的相互作用。出生后头几天的疾病严重程度，而不仅仅是最初的缺氧缺血事件期间的严重程度，是接受治疗性低温（TH）治疗的NE新生儿不良结局的重要预测指标。因此，我们提出了一套专门用于支持受损新生儿大脑的护理实践方案，该方案基于每个器官系统的当前最佳证据。使用该方案对NE结局的影响仍有待证实。
