代谢相关脂肪性肝病与不良母婴结局：一项系统评价和荟萃分析。
Metabolic associated fatty liver disease and adverse maternal and fetal outcomes: a systematic review and meta-analysis.
作者信息
Dyah Adinda Ayu, Rahadina Rahadina
机构信息
Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
出版信息
Clin Exp Hepatol. 2021 Sep;7(3):305-311. doi: 10.5114/ceh.2021.109228. Epub 2021 Sep 20.
AIM OF THE STUDY
Metabolic-associated fatty liver disease (MAFLD) is now the most prevalent chronic liver disease in the world. Its prevalence in women of reproductive age is approximately 10%. Due to its high prevalence in this specific population, it is important to investigate adverse maternal and fetal outcomes caused by MAFLD during pregnancy. We aimed to summarize the association between MAFLD and adverse maternal and fetal outcomes.
MATERIAL AND METHODS
A search was conducted on PubMed and ProQuest from inception to April 1, 2021, for studies assessing the association between MAFLD and adverse maternal and fetal outcomes. The quality of included studies was assessed using the Newcastle-Ottawa scale (NOS). We analyzed the pooled odds ratios (ORs) with 95% confidence intervals (CIs) using a fixed and random-effects model. Heterogeneity was assessed using .
RESULTS
Six studies comprising 20,535,994 (5,964 MAFLD) pregnant women were included. The quality of studies ranged from 6 to 8 stars. MAFLD was significantly associated with increased risk of dysglycemia (OR = 3.65, 95% CI = 2.47-5.39), pregnancy-associated hypertension (OR = 3.27, 95% CI = 2.75-3.88), cesarean section (OR = 2.78, 95% CI = 1.60-4.83), and preterm birth (OR = 1.70, 95% CI = 1.37-2.10) but not large for gestational age (OR = 1.69, 95% CI = 0.64-4.45).
CONCLUSIONS
The presence of MAFLD is associated with adverse maternal and fetal outcomes.
研究目的
代谢相关脂肪性肝病（MAFLD）是目前全球最普遍的慢性肝病。其在育龄女性中的患病率约为10%。由于其在这一特定人群中的高患病率，研究孕期MAFLD导致的不良母婴结局具有重要意义。我们旨在总结MAFLD与不良母婴结局之间的关联。
材料与方法
在PubMed和ProQuest数据库中从建库至2021年4月1日进行检索，以查找评估MAFLD与不良母婴结局之间关联的研究。使用纽卡斯尔-渥太华量表（NOS）评估纳入研究的质量。我们采用固定效应模型和随机效应模型分析合并比值比（OR）及95%置信区间（CI）。使用 评估异质性。
结果
纳入了6项研究，共20,535,994名（5964名MAFLD患者）孕妇。研究质量从6星到8星不等。MAFLD与血糖异常风险增加（OR = 3.65，95% CI = 2.47 - 5.39）、妊娠相关高血压（OR = 3.27，95% CI = 2.75 - 3.88）、剖宫产（OR = 2.78，95% CI = 1.60 - 4.83）和早产（OR = 1.70，95% CI = 1.37 - 2.10）显著相关，但与大于胎龄儿无关（OR = 1.69，95% CI = 0.64 - 4.45）。
结论
MAFLD与不良母婴结局相关。
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