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建设印度生物铸造厂:挑战与前进道路。

Building Biofoundry India: challenges and path forward.

作者信息

Panda Binay, Dhar Pawan K

机构信息

Biofoundry India, School of Biotechnology, Jawaharlal Nehru University, New Delhi, India.

出版信息

Synth Biol (Oxf). 2021 Jun 25;6(1):ysab015. doi: 10.1093/synbio/ysab015. eCollection 2021.

Abstract

Biofoundry is a place where biomanufacturing meets automation. The highly modular structure of a biofoundry helps accelerate the design-build-test-learn workflow to deliver products fast and in a streamlined fashion. In this perspective, we describe our efforts to build Biofoundry India, where we see the facility add a substantial value in supporting research, innovation and entrepreneurship. We describe three key areas of our focus, harnessing the potential of non-expressing parts of the sequenced genomes, using deep learning in pathway reconstruction and synthesising enzymes and metabolites. Toward the end, we describe specific challenges in building such facility in India and the path to mitigate some of those working with the other biofoundries worldwide.

摘要

生物铸造厂是生物制造与自动化相结合的场所。生物铸造厂高度模块化的结构有助于加速设计-构建-测试-学习工作流程,从而快速、高效地交付产品。从这个角度来看,我们描述了建立印度生物铸造厂的努力,我们认为该设施在支持研究、创新和创业方面具有重大价值。我们描述了三个重点领域,即利用已测序基因组中不表达部分的潜力、在途径重建中使用深度学习以及合成酶和代谢物。最后,我们描述了在印度建立这样一个设施所面临的具体挑战,以及与全球其他生物铸造厂合作以缓解其中一些挑战的途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37a3/8546612/58abfb2e4488/ysab015f1.jpg

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