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以间隔为主且不累及心尖的应变模式的野生型心脏淀粉样变性非典型病例。

Atypical Case of Wild-Type Cardiac Amyloidosis with Septal Predominance and a Nonapical Sparing Strain Pattern.

作者信息

Hussain Muzna, Hanna Mazen, Jaber Wael, Collier Patrick

机构信息

Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio.

出版信息

CASE (Phila). 2021 Aug 18;5(5):313-317. doi: 10.1016/j.case.2021.07.010. eCollection 2021 Oct.

DOI:10.1016/j.case.2021.07.010
PMID:34712876
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8530817/
Abstract

• We present an atypical variant case of wild-type transthyretin cardiac amyloidosis. • Amyloid deposition occurred mainly in the interventricular septum. • The classic apical sparing pattern was absent, despite other suggestive findings. • A high index of suspicion for amyloid should still be sought in such cases. • Multimodality imaging should be considered to investigate variant amyloid forms.

摘要

• 我们报告了一例野生型转甲状腺素蛋白心脏淀粉样变性的非典型变异病例。

• 淀粉样沉积主要发生在室间隔。

• 尽管有其他提示性发现，但经典的心尖 sparing 模式不存在。

• 在此类病例中仍应高度怀疑淀粉样变性。

• 应考虑采用多模态成像来研究变异型淀粉样蛋白形式。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0328/8530817/105f89fc12d9/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0328/8530817/90710a410260/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0328/8530817/c58c48a72885/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0328/8530817/1687d4efadd6/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0328/8530817/70f4097d7f62/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0328/8530817/7c6fb54a6ae2/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0328/8530817/105f89fc12d9/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0328/8530817/90710a410260/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0328/8530817/c58c48a72885/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0328/8530817/1687d4efadd6/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0328/8530817/70f4097d7f62/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0328/8530817/7c6fb54a6ae2/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0328/8530817/105f89fc12d9/gr5.jpg

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本文引用的文献

1
Atypical Case of Epicardial Amyloid Mass without Classical Features of Myocardial Infiltration.无心肌浸润典型特征的心外膜淀粉样物质肿块的非典型病例。
CASE (Phila). 2020 Mar 30;4(3):160-165. doi: 10.1016/j.case.2019.12.003. eCollection 2020 Jun.
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Cardiac Amyloidosis: Evolving Diagnosis and Management: A Scientific Statement From the American Heart Association.心脏淀粉样变性：不断发展的诊断和治疗——美国心脏协会的科学声明。
Circulation. 2020 Jul 7;142(1):e7-e22. doi: 10.1161/CIR.0000000000000792. Epub 2020 Jun 1.
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Epidemiologic and Survival Trends in Amyloidosis, 1987-2019.
1987 - 2019年淀粉样变性的流行病学及生存趋势
N Engl J Med. 2020 Apr 16;382(16):1567-1568. doi: 10.1056/NEJMc1917321.
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Cardiac Amyloidosis: Mimics, Multimodality Imaging Diagnosis, and Treatment.心脏淀粉样变性：模仿者、多模态成像诊断与治疗
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Transthyretin Cardiac Amyloidosis: A Noninvasive Multimodality Approach to Diagnosis Using Transthoracic Echocardiography, 99m-Tc-Labeled Phosphate Bone Scanning, and Cardiac Magnetic Resonance Imaging.转甲状腺素蛋白型心脏淀粉样变性：一种使用经胸超声心动图、99m锝标记的磷酸盐骨扫描和心脏磁共振成像进行诊断的非侵入性多模态方法。
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Regional Variation in Technetium Pyrophosphate Uptake in Transthyretin Cardiac Amyloidosis and Impact on Mortality.转甲状腺素蛋白心脏淀粉样变中焦磷酸盐摄取的区域差异及其对死亡率的影响。
JACC Cardiovasc Imaging. 2018 Feb;11(2 Pt 1):234-242. doi: 10.1016/j.jcmg.2017.06.020. Epub 2017 Oct 5.
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Nonbiopsy Diagnosis of Cardiac Transthyretin Amyloidosis.非活检诊断心脏转甲状腺素淀粉样变性。
Circulation. 2016 Jun 14;133(24):2404-12. doi: 10.1161/CIRCULATIONAHA.116.021612. Epub 2016 Apr 22.
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