Kappler J W, Wade T, White J, Kushnir E, Blackman M, Bill J, Roehm N, Marrack P
Cell. 1987 Apr 24;49(2):263-71. doi: 10.1016/0092-8674(87)90567-8.
We have identified in mice an allele of a new T cell receptor V beta gene, V beta 17a, whose product is bound by the monoclonal antibody KJ23a. Over 90% of T cell hybridomas prepared from V beta 17a+ T cells of SWR mice respond to allogeneic forms of the IE class II MHC protein, indicating that V beta 17a has an appreciable affinity for IE regardless of the other components of the T cell receptor. These results suggest a bias in the germ-line T cell receptor repertoire toward recognition of MHC proteins and indicate that the V beta portion of the receptor may form the most important contact points with MHC ligands.
我们在小鼠中鉴定出一种新的T细胞受体Vβ基因Vβ17a的一个等位基因，其产物可与单克隆抗体KJ23a结合。从SWR小鼠的Vβ17a+ T细胞制备的超过90%的T细胞杂交瘤对II类MHC蛋白IE的同种异型形式有反应，这表明无论T细胞受体的其他成分如何，Vβ17a对IE都有明显的亲和力。这些结果表明种系T细胞受体库在识别MHC蛋白方面存在偏向性，并表明受体的Vβ部分可能与MHC配体形成最重要的接触点。
