State Key Laboratory of Bioelectronics & National Demonstration Centre for Experimental Biomedical Engineering Education, School of Biological Science and Medical Engineering, Southeast University, Nanjing, 210096, P. R. China.
Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, P. R. China.
Small. 2021 Dec;17(50):e2103997. doi: 10.1002/smll.202103997. Epub 2021 Oct 28.
Wound care is still worthy of concern, and effective measures such as electrical stimulating therapy (EST) have sparked compellingly for wound repair. Especially, portable and point-of-care EST devices get extremely desired but these are often limited by inevitable external power sources, lack of biological functions, and mechanical properties conforming to skin tissue. Herein, a dress-on-person self-powered nanocomposite bioactive repairer of wound is designed. As such, the cooperation of the film prepared by layer-by-layer self-assembling 2-hydroxypropyltrimethyl ammonium chloride chitosan (HTCC), alginate (ALG), and poly-dopamine/Fe nanoparticles (PFNs), with a self-powered nanogenerator (SN) driven by motion into a nanocomposite repairer (HAP/SN-NR) is conducted. The HAP/SN-NR not only guides cell behavior (proliferation and migration rate ≈61.7%, ≈52.3%), but also facilitates neovascularization (enhanced CD31 expression >4-fold) through its self-powered EST, and the endogenous wound closure with no inflammatory in rats owing to reactive oxygen species (ROS)-clearance of HAP/SN-NR in vitro/vivo through responsively releasing poly-dopamine nanoparticles at wound pH. Enormous efforts illustrate that the repairer is endowed with high self-adhesion to tissue, self-healing, and biodegradation, accelerating wound healing (50% closure ≈5 days). This strategy sheds light on novel multifunctional portable sensor-type dressings and propels the development of intelligent medical devices.
伤口护理仍然值得关注，电刺激疗法（EST）等有效措施激发了人们对伤口修复的强烈兴趣。特别是，便携式即时 EST 设备受到了极大的需求，但这些设备通常受到不可避免的外部电源、缺乏生物功能以及与皮肤组织机械性能相匹配的限制。在此，设计了一种可穿戴的自供电纳米复合生物活性伤口修复器。为此，通过层层自组装 2-羟丙基三甲基氯化铵壳聚糖（HTCC）、海藻酸钠（ALG）和聚多巴胺/Fe 纳米粒子（PFNs）制备的薄膜与运动驱动的自供电纳米发电机（SN）合作，形成了纳米复合修复器（HAP/SN-NR）。HAP/SN-NR 不仅通过自供电 EST 引导细胞行为（增殖和迁移率≈61.7%，≈52.3%），而且还通过其自身的 EST 促进新血管生成（增强的 CD31 表达>4 倍），并且由于 HAP/SN-NR 在体外/体内通过响应性释放聚多巴胺纳米粒子清除活性氧（ROS），因此在大鼠中无需炎症即可实现内源性伤口闭合。大量研究表明，修复器具有高组织自粘性、自愈合性和生物降解性，可加速伤口愈合（50%闭合≈5 天）。该策略为新型多功能便携式传感器型敷料提供了思路，并推动了智能医疗设备的发展。
