1 型多发性内分泌肿瘤中的胰腺神经内分泌肿瘤主要位于背侧体：一项内镜超声研究。

Pancreatic Neuroendocrine Neoplasias in Multiple Endocrine Neoplasia Type 1 Are Predominantly Located in the Dorsal Anlage: An Endoscopic Ultrasound Study.

机构信息

From the Centre for Endocrinology, Diabetology & Osteology, Endocrine Laboratory, Philipp's University and University Hospital, Marburg.

Department of Visceral, Thoracic and Vascular Surgery, Philipp's University and University Hospital, Marburg, Germany.

出版信息

Pancreas. 2021 Sep 1;50(8):1169-1172. doi: 10.1097/MPA.0000000000001890.

DOI:10.1097/MPA.0000000000001890

PMID:34714280

Abstract

OBJECTIVES

Pancreatic neuroendocrine neoplasias (pNENs) frequently occur in multiple endocrine neoplasia type 1 (MEN1). Their distribution referring to embryology, that is, the pancreatic anlagen, has not been investigated yet.

METHODS

In the time between 1998 and 2019, we studied the distribution of pNENs in MEN1 concerning the embryologic origin of the pancreas, that is, the dorsal versus ventral anlage using endoscopic ultrasound in 117 MEN1 patients: 56 women, 61 men; aged 40 years (standard deviation, 14 years) at first endoscopic ultrasound.

RESULTS

In 105 patients, a total of 628 pNENs were detected. They were located in the pancreatic tail: 231; pancreatic body: 177; pancreatic head/uncinate process: 220. Of the latter, 22 were located in the ventral anlage, 176 in the dorsal anlage, and 22 remained undefined. In summary, just 3.5% of all detected pNENs were located in the ventral anlage, 93.0% in the dorsal anlage, and 3.5% could not be assigned.

CONCLUSIONS

Our study indicates that the vast majority of pNENs in MEN1 is located in the dorsal anlage, whereas the ventral anlage of the pancreas seems to be to a large extend spared from pNENs. Implications for new surgical strategies might be considered.

摘要

目的

胰腺神经内分泌肿瘤（pNENs）常发生于多发性内分泌肿瘤 1 型（MEN1）。其分布与胚胎学相关，即胰腺原基，尚未得到研究。

方法

在 1998 年至 2019 年期间，我们研究了 117 例 MEN1 患者的胰腺原基（背侧与腹侧原基）与 pNENs 分布的关系，使用内镜超声对 56 名女性和 61 名男性患者进行研究，年龄为首次内镜超声时的 40 岁（标准差 14 岁）。

结果

在 105 例患者中，共检测到 628 个 pNENs。它们位于胰尾：231 个；胰体：177 个；胰头/钩突：220 个。其中，22 个位于腹侧原基，176 个位于背侧原基，22 个未确定位置。总的来说，所有检测到的 pNENs 中仅有 3.5%位于腹侧原基，93.0%位于背侧原基，3.5%无法确定位置。