von Stillfried Saskia, Boor Peter
Institut für Pathologie, Universitätsklinik RWTH Aachen, Pauwelsstr. 30, 52074, Aachen, Deutschland.
Medizinische Klinik II (Nephrologie und Immunologie), Universitätsklinik RWTH Aachen, Aachen, Deutschland.
Pathologe. 2021 Dec;42(Suppl 2):129-134. doi: 10.1007/s00292-021-01004-w. Epub 2021 Oct 29.
Autopsies are an important tool for understanding novel diseases, including COVID-19.
The German Registry of COVID-19 Autopsies (DeRegCOVID) was established and launched in April 2020. DeRegCOVID acts as the electronic backbone of the German Network for Autopsies in Pandemics (DEFEAT PANDEMIcs), which started in September 2020.
The results of DeRegCOVID and DEFEAT PANDEMIcs are characterized by an unprecedented collaboration of more than 35 university and non-university autopsy centers linking pathological, neuropathological, and forensic medicine institutes. DeRegCOVID has evolved, adapted to new challenges, and currently contains the largest international autopsy dataset. After only a short period of operation, more than 80 publications have been produced, which have contributed to the understanding of the pathogenesis of COVID-19, e.g., through the discovery of thromboembolic events, multiorgan tropism, and NeuroCovid-19. The autopsy centers have carried out extensive educational work and, beyond the scientific gain in knowledge, have explained to politicians and the general public the essential role of autopsies in pandemic management. To further develop autopsy-driven research, a continuation of DEFEAT PANDEMIcs was conceived, the National Autopsy Network (NATON).
The registry and network, in which all interested centers can participate, have demonstrated the value of networked medical research and the high value of autopsy for medicine.
尸检是了解包括新冠病毒病（COVID-19）在内的新型疾病的重要工具。
德国COVID-19尸检登记处（DeRegCOVID）于2020年4月设立并启动。DeRegCOVID是德国大流行尸检网络（DEFEAT PANDEMIcs）的电子支柱，该网络于2020年9月启动。
DeRegCOVID和DEFEAT PANDEMIcs的成果体现了35多个大学和非大学尸检中心前所未有的合作，这些中心连接了病理、神经病理和法医学研究所。DeRegCOVID不断发展，适应新挑战，目前拥有最大的国际尸检数据集。在短短运营一段时间后，已发表了80多篇论文，这些论文有助于理解COVID-19的发病机制，例如通过发现血栓栓塞事件、多器官嗜性和神经型COVID-19。尸检中心开展了广泛的教育工作，除了获得科学知识外，还向政界人士和公众解释了尸检在大流行管理中的重要作用。为了进一步发展基于尸检的研究，构思了DEFEAT PANDEMIcs的延续项目——国家尸检网络（NATON）。
该登记处和网络让所有感兴趣的中心都能参与，证明了网络医学研究的价值以及尸检对医学的高价值。
