Department of Anaesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany.
Department of Anaesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany.
Clin Neurophysiol. 2021 Dec;132(12):2959-2964. doi: 10.1016/j.clinph.2021.09.005. Epub 2021 Oct 5.
The electroencephalographic derived indices have been developed for adult patients, however these monitors have not been validated for infants.
Frontal EEGs were recorded in 115 infants aged <1 year [0-3-months (N = 27), 4-6-months (N = 30), 7-9-months (N = 29) and 10-12-months (N = 29)] who received general anaesthesia with sevoflurane. Total power (µV) and relative β-, α-, θ-, δ-power (%) were analyzed. Additionally, in 20 EEGs event marker were added (baseline, loss of consciousness, intraoperative situation, extubation) to assess perioperative EEG dynamics.
Newborns show a mean relative δ-power at 80% in intraoperative EEG compared to infants (10-12 months) showing 47.5%. Relative β-power and α-power are low in newborns (mean 3.2% and 4.6%; respectively), with a marked increase in the older infants (4-6 months) (mean 10.9% and 14.4%; respectively). EEG dynamic in newborns from baseline (relative δ-power of 88%) to the intraoperative situation (80.5%) are discrete. In contrast infants >6-months have a strong reduction of relative δ-power from baseline to the intraoperative situation, which corresponds to an increase of faster frequencies.
Age dependent perioperative EEG signatures can be demonstrated in infants younger than one year.
We demonstrate significant differences in EEG readouts between newborns and infants which questions our monitoring systems in paediatric anaesthesia.
脑电衍生指标已为成人患者开发，然而这些监测仪尚未在婴儿中验证。
记录了 115 名年龄<1 岁的婴儿（0-3 个月（N=27）、4-6 个月（N=30）、7-9 个月（N=29）和 10-12 个月（N=29））的额部脑电图，他们接受七氟醚全身麻醉。分析总功率（µV）和相对β-、α-、θ-、δ-功率（%）。此外，在 20 个脑电图中添加了事件标记（基线、意识丧失、手术期间、拔管），以评估围手术期脑电图动态。
与婴儿（10-12 个月）相比，新生儿在术中脑电图中表现出相对δ-功率的平均值为 80%，而婴儿（10-12 个月）为 47.5%。新生儿的相对β-和α-功率较低（平均值分别为 3.2%和 4.6%），而年龄较大的婴儿（4-6 个月）明显增加（平均值分别为 10.9%和 14.4%）。新生儿从基线（相对δ-功率为 88%）到术中情况（80.5%）的脑电图动态是离散的。相比之下，6 个月以上的婴儿从基线到手术期间相对δ-功率有明显下降，这对应于更快频率的增加。
在年龄<1 岁的婴儿中可以证明与年龄相关的围手术期脑电图特征。
我们在新生儿和婴儿之间的脑电图读数中发现了显著差异，这对我们在小儿麻醉中的监测系统提出了质疑。
