红细胞硫氰酸酶：其在调节哺乳动物δ-氨基-γ-酮戊酸合成酶活性中的可能作用。
Red blood cell rhodanese: its possible role in modulating delta-aminolaevulinate synthetase activity in mammals.
作者信息
Vazquez E, Buzaleh A M, Wider E, Batlle A M
出版信息
Int J Biochem. 1987;19(2):217-9. doi: 10.1016/0020-711x(87)90337-5.
The optimum conditions for measuring rhodanese activity in human erythrocytes were established. The mean control values for males (112 nmol SCN/30 min/mg protein) and females (127 nmol SCN/30 min/mg protein) were determined. Rhodanese activity was measured in different porphyric patients. The activity was diminished in porphyria cutanea tarda (PCT), acute intermittent porphyria (AIP), variegate porphyria (VP) and lead intoxication (Pb), remaining normal in erythropoietic protoporphyria (EPP). delta-Aminolaevulinate synthetase (ALA-S) activity was increased in PCT, AIP, VP and Pb showing no changes in EPP. It is suggested that a similar scheme, to that proposed for the control of ALA-S in Rhodopseudomonas spheroides and soybean callus, is also operating in animals.
确定了测量人体红细胞中硫氰酸酶活性的最佳条件。测定了男性（112 nmol SCN/30分钟/毫克蛋白质）和女性（127 nmol SCN/30分钟/毫克蛋白质）的平均对照值。在不同的卟啉症患者中测量了硫氰酸酶活性。迟发性皮肤卟啉症（PCT）、急性间歇性卟啉症（AIP）、混合型卟啉症（VP）和铅中毒（Pb）患者的硫氰酸酶活性降低，而红细胞生成性原卟啉症（EPP）患者的硫氰酸酶活性保持正常。PCT、AIP、VP和Pb患者的δ-氨基乙酰丙酸合成酶（ALA-S）活性增加，EPP患者无变化。有人提出，在动物中也存在一种类似于在球形红假单胞菌和大豆愈伤组织中控制ALA-S的机制。
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