The Eye Center, Southern College of Optometry Memphis, TN, USA.
Anglia Ruskin University, Vision and Hearing Sciences Research Centre, Cambridge, United Kingdom.
Cont Lens Anterior Eye. 2022 Feb;45(1):101529. doi: 10.1016/j.clae.2021.101529. Epub 2021 Oct 26.
To establish the time course of lid wiper epitheliopathy (LWE) in established CL wearers after a single day (6-10 h) of daily disposable contact lens (CL) wear, the following day post-CL removal and 1-week after CL discontinuation.
Twenty-one symptomatic (CLDEQ-8 score ≥ 12) habitual wearers of MyDay® silicone hydrogel daily disposable were included. LWE staining was assessed prior to CL wear (Visit 1, V1) using semi-automated analysis after instillation of two drops of 1 % lissamine green (10 μL) that were applied to the superior bulbar conjunctiva. LWE measurements were repeated after 6-10 h of continuous CL wear (Visit 2, V2), post-CL removal the following day (Visit 3, V3) and after 1-week CL discontinuation (Visit 4, V4). At each visit, ocular symptoms were evaluated using the SPEED-8 questionnaire and set of 0-100 visual analogue scales (VAS).
LWE showed no significant changes after 6-10 h of continuous CL wear (p = 0.536), post-CL removal the following day (p = 0.677) or following 1-week of CL discontinuation (p = 0.478). Analysis revealed a significant improvement in symptomatology between V1 and V2 (SPEED-8, p < 0.01) and also improvements in the 0-100 VAS scores between V2 and V4 for average daily dryness (p < 0.01), end-of-day dryness (p < 0.01) and frequency of end-of-day dryness (p < 0.05).
The present data suggest that the etiology of LWE is multifactorial and the sole intervention of temporarily discontinuing CL wear does not lead to resolution of these clinical signs.
在连续佩戴每日一次性隐形眼镜（CL） 6-10 小时（即 1 天）后、次日 CL 取出后和 CL 停戴 1 周后，确定已建立的 CL 佩戴者中 lid wiper epitheliopathy（LWE）的时间进程。
纳入 21 名有症状的（CLDEQ-8 评分≥12）MyDay®硅水凝胶日戴型每日一次性隐形眼镜佩戴者。在 CL 佩戴前（第 1 次就诊，V1）使用半自动化分析，在将 2 滴 1% Lissamine Green（10μL）滴到上球结膜后评估 LWE 染色。在连续佩戴 CL 6-10 小时后（第 2 次就诊，V2）、次日 CL 取出后（第 3 次就诊，V3）和 CL 停戴 1 周后（第 4 次就诊，V4）重复 LWE 测量。在每次就诊时，使用 SPEED-8 问卷和 0-100 视觉模拟量表（VAS）评估眼部症状。
连续佩戴 CL 6-10 小时后（p=0.536）、次日 CL 取出后（p=0.677）或 CL 停戴 1 周后（p=0.478），LWE 均无显著变化。分析显示，在 V1 和 V2 之间症状学有显著改善（SPEED-8，p<0.01），在 V2 和 V4 之间 0-100 VAS 评分也有改善，包括平均每日干燥度（p<0.01）、结束时干燥度（p<0.01）和结束时干燥频率（p<0.05）。
本研究数据表明，LWE 的病因是多因素的，暂时停止 CL 佩戴并不能导致这些临床体征的缓解。
