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中国男男性行为者使用 HIV 暴露前预防的意愿、偏好方式和潜在障碍。

Willingness, preferred ways and potential barriers to use pre-exposure prophylaxis for HIV prevention among men who have sex with men in China.

机构信息

Xiangya School of Nursing, Central South University, Changsha, Hunan, China.

School of Health, Federation University Australia, Melbourne, Victoria, Australia.

出版信息

BMJ Open. 2021 Oct 29;11(10):e053634. doi: 10.1136/bmjopen-2021-053634.

Abstract

OBJECTIVE

To explore willingness and preferred ways to use HIV pre-exposure prophylaxis (PrEP), factors associated with willingness, and potential barriers to PrEP use among men who have sex with men (MSM) in Changsha, China.

DESIGN

A cross-sectional survey was conducted from 25 June to 31 August 2019. Two hundred and fifty-five MSM were recruited from three community-based organisations (CBOs) in Changsha City. Willingness and potential barriers to use PrEP were examined using researcher-created scales. Univariate and multivariate logistic regression was used to analyse the factors associated with willingness to use PrEP. P values <0.05 were considered significant.

SETTING

Three MSM inclusive CBOs in Changsha, Hunan Province, China.

PARTICIPANTS

255 HIV-negative MSM were recruited through their CBOs with snowball sampling.

RESULTS

Less than half of the participants (43.1%) had heard of PrEP and 15.3% were willing to use PrEP. The participants reported higher willingness to use event-driven PrEP (3.70±0.07) than daily PrEP (2.65±0.07). Higher self-rated risk and fear of contracting HIV (OR: 14.47, 95% CI 2.19 to 95.53), awareness of PrEP (OR: 4.20, 95% CI 1.64 to 10.73), sharing one's own sexual orientation with parents or siblings (OR: 2.52, 95% CI 1.54 to 7.20) and having a university education or above (OR:0.29, 95% CI 0.12 to 0.72) were associated with willingness to use PrEP. Only 12.2% of the sample was concerned about potential barriers to PrEP use.

CONCLUSION

Efforts to improve awareness and knowledge of PrEP, teach self-evaluation of HIV infection risk and provide social and emotional support for MSM are needed to scale up PrEP implementation in China.

摘要

目的

探索中国长沙市男男性行为者(MSM)使用 HIV 暴露前预防(PrEP)的意愿和偏好方式、与使用意愿相关的因素,以及 PrEP 使用的潜在障碍。

设计

2019 年 6 月 25 日至 8 月 31 日进行了一项横断面调查。从长沙市三个社区组织(CBO)招募了 255 名 MSM。使用研究人员创建的量表评估使用 PrEP 的意愿和潜在障碍。使用单变量和多变量逻辑回归分析与使用 PrEP 意愿相关的因素。P 值<0.05 被认为具有统计学意义。

地点

中国湖南省长沙市三个 MSM 包容性 CBO。

参与者

通过 CBO 采用雪球抽样法招募了 255 名 HIV 阴性 MSM。

结果

不到一半的参与者(43.1%)听说过 PrEP,15.3%表示愿意使用 PrEP。参与者报告称,他们更愿意使用事件驱动型 PrEP(3.70±0.07),而不是每日 PrEP(2.65±0.07)。更高的自我评估风险和担心感染 HIV(OR:14.47,95%CI 2.19 至 95.53)、对 PrEP 的认识(OR:4.20,95%CI 1.64 至 10.73)、与父母或兄弟姐妹分享自己的性取向(OR:2.52,95%CI 1.54 至 7.20)和拥有大学学历或以上(OR:0.29,95%CI 0.12 至 0.72)与使用 PrEP 的意愿相关。只有 12.2%的样本对 PrEP 使用的潜在障碍表示担忧。

结论

需要努力提高 MSM 对 PrEP 的认识和了解,教授 HIV 感染风险的自我评估,并为 MSM 提供社会和情感支持,以扩大中国 PrEP 的实施。

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