Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Central Laboratory, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China.
Arch Osteoporos. 2021 Oct 30;16(1):161. doi: 10.1007/s11657-021-01030-4.
Both anemia and osteoporosis are common in type 2 diabetes mellitus (T2DM). However, the relationship between them remains to be determined. This study showed that anemia was related to osteoporosis in male and female T2DM patients. Diabetes patients with anemia should also be wary of osteoporosis.
Anemia and osteoporosis are considered complications of type 2 diabetes mellitus (T2DM). However, the relationship between anemia and osteoporosis in the T2DM population remains to be determined. Thus, we planned the present study to verify their relationship.
A retrospective cross-sectional study was performed. The patients were divided into groups according to sex and hemoglobin levels (Q1: ≤ 120, Q2: 120 to ≤ 140, Q3: > 140 in men; Q1: ≤ 110, Q2: 110 to ≤ 130, Q3: > 130 in women). Clinical characteristics and bone mineral density (BMD) were compared. The relationship between anemia and osteoporosis was determined after adjusting for age, diabetic duration, body mass index, alanine aminotransferase, creatinine, HbA1c, and fasting C-peptide. Statistical analysis was performed using SPSS 26.0.
This study included 2336 patients (1150 men and 1186 postmenopausal women). The percentage of osteoporosis differed by hemoglobin status in both men (Q1: 20.2%, Q2: 15.5%, Q3: 12.4%, P = 0.031) and women (Q1: 51.4%, Q2: 38.0%, Q3: 34.5%, P < 0.001). Q1, with the lowest hemoglobin level, has higher percentage of osteoporosis in men (20.2%) and in women (51.4%). Hip BMD (men: r = 0.168, P < 0.001, women: r = 0.126, P < 0.001) and femur neck BMD (men: r = 0.150, P < 0.001, women: r = 0.134, P < 0.001) were correlated with hemoglobin levels in both sexes. The odds of osteoporosis increased 1.4-fold in men and 2.0-fold in women in the Q1 groups compared with Q3 groups.
Anemia was related to osteoporosis in T2DM patients regardless of sex. Diabetic patients with anemia (men with hemoglobin below 120 g/L and women with hemoglobin below 110 g/L) should also be wary of osteoporosis.
本研究旨在验证贫血与 2 型糖尿病（T2DM）患者骨质疏松症之间的关系。
采用回顾性横断面研究。根据性别和血红蛋白水平（男性：Q1：≤120，Q2：120 至≤140，Q3：＞140；女性：Q1：≤110，Q2：110 至≤130，Q3：＞130）将患者分为组。比较临床特征和骨密度（BMD）。调整年龄、糖尿病病程、体重指数、丙氨酸氨基转移酶、肌酐、HbA1c 和空腹 C 肽后，确定贫血与骨质疏松症之间的关系。使用 SPSS 26.0 进行统计分析。
本研究共纳入 2336 例患者（男性 1150 例，绝经后女性 1186 例）。男性（Q1：20.2%，Q2：15.5%，Q3：12.4%，P=0.031）和女性（Q1：51.4%，Q2：38.0%，Q3：34.5%，P＜0.001）中，骨质疏松症的发生率随血红蛋白水平的不同而不同。男性（Q1：20.2%）和女性（Q1：51.4%）中血红蛋白水平最低的 Q1 组骨质疏松症发生率更高。男性髋部 BMD（r=0.168，P＜0.001）和女性髋部 BMD（r=0.126，P＜0.001）与血红蛋白水平呈正相关。与 Q3 组相比，Q1 组男性（OR=1.4，95%CI：1.0-1.9）和女性（OR=2.0，95%CI：1.4-2.8）骨质疏松症的发生风险增加 1.4 倍和 2.0 倍。
贫血与 T2DM 患者的骨质疏松症有关，无论性别如何。贫血的糖尿病患者（男性血红蛋白＜120g/L，女性血红蛋白＜110g/L）也应警惕骨质疏松症。
