Zhang Mengdi, Cui Yaru, Cheng Yao, Wang Qiaoyun, Sun Hongliu
School of Pharmaceutical Sciences, Binzhou Medical University, Yantai, China.
J Neurosci Res. 2021 Dec;99(12):3274-3283. doi: 10.1002/jnr.24958. Epub 2021 Oct 29.
Xenon is an inert gas with stable chemical properties which is used as an anesthetic. Recent in vitro and in vivo findings indicate that xenon also elicits an excellent neuroprotective effect in subanesthetic concentrations. The mechanisms underlying this primarily involve the attenuation of excitotoxicity and the inhibition of N-methyl-d-aspartic acid (NMDA) receptors and NMDA receptor-related effects, such as antioxidative effects, reduced activation of microglia, and Ca -dependent mechanisms, as well as the interaction with certain ion channels and glial cells. Based on this strong neuroprotective role, a large number of experimental and clinical studies have confirmed the significant therapeutic effect of xenon in the treatment of neurological diseases. This review summarizes the reported neuroprotective mechanisms of xenon and discusses its possible therapeutic application in the treatment of various neurological diseases.
氙是一种化学性质稳定的惰性气体，用作麻醉剂。最近的体外和体内研究结果表明，氙在亚麻醉浓度下也具有出色的神经保护作用。其潜在机制主要包括减轻兴奋性毒性、抑制N-甲基-D-天冬氨酸（NMDA）受体及与NMDA受体相关的效应，如抗氧化作用、小胶质细胞激活减少和钙依赖性机制，以及与某些离子通道和神经胶质细胞的相互作用。基于这种强大的神经保护作用，大量实验和临床研究证实了氙在治疗神经疾病方面的显著治疗效果。本文综述了已报道的氙的神经保护机制，并探讨了其在治疗各种神经疾病中的可能治疗应用。
