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非侵入性脑刺激技术在改善阅读障碍中的应用:系统综述。

The use of noninvasive brain stimulation techniques to improve reading difficulties in dyslexia: A systematic review.

机构信息

Lise Meitner Research Group Cognition and Plasticity, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.

Alexander von Humboldt Foundation, Berlin, Germany.

出版信息

Hum Brain Mapp. 2022 Feb 15;43(3):1157-1173. doi: 10.1002/hbm.25700. Epub 2021 Oct 30.

Abstract

Noninvasive brain stimulation (NIBS) allows to actively and noninvasively modulate brain function. Aside from inhibiting specific processes, NIBS may also enhance cognitive functions, which might be used for the prevention and intervention of learning disabilities such as dyslexia. However, despite the growing interest in modulating learning abilities, a comprehensive, up-to-date review synthesizing NIBS studies with dyslexics is missing. Here, we fill this gap and elucidate the potential of NIBS as treatment option in dyslexia. The findings of the 15 included studies suggest that repeated sessions of reading training combined with different NIBS protocols may induce long-lasting improvements of reading performance in child and adult dyslexics, opening promising avenues for future research. In particular, the "classical" reading areas seem to be most successfully modulated through NIBS, and facilitatory protocols can improve various reading-related subprocesses. Moreover, we emphasize the need to further explore the potential to modulate auditory cortex function as a preintervention and intervention approach for affected children, for example, to avoid the development of auditory and phonological difficulties at the core of dyslexia. Finally, we outline how future studies may increase our understanding of the neurobiological basis of NIBS-induced improvements in dyslexia.

摘要

非侵入性脑刺激(NIBS)可主动且非侵入地调节大脑功能。除了抑制特定的过程外,NIBS 还可能增强认知功能,这可能用于预防和干预学习障碍,如阅读障碍。然而,尽管人们对调节学习能力的兴趣日益浓厚,但仍缺乏对阅读障碍者进行 NIBS 研究的全面、最新综述。在这里,我们填补了这一空白,并阐明了 NIBS 作为阅读障碍治疗选择的潜力。15 项纳入研究的结果表明,重复的阅读训练结合不同的 NIBS 方案可能会诱导儿童和成人阅读障碍者阅读表现的持久改善,为未来的研究开辟了有希望的途径。特别是,“经典”阅读区域似乎通过 NIBS 得到了最成功的调节,促进性方案可以改善各种与阅读相关的子过程。此外,我们强调需要进一步探索调节听觉皮层功能的潜力,作为受影响儿童的预干预和干预方法,例如,避免阅读障碍核心的听觉和语音困难的发展。最后,我们概述了未来的研究如何增加我们对 NIBS 诱导阅读障碍改善的神经生物学基础的理解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4356/8764483/27b12e70627e/HBM-43-1157-g002.jpg

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