氨基酸可预测急性呼吸困难患者的预后。
Amino acids predict prognosis in patients with acute dyspnea.
机构信息
The Department of Clinical Sciences Malmo, Faculty of Medicine, Lund University, Malmo, Sweden.
The Department of Anesthesiology and Intensive care, NU-Hospital group, Trollhattan/Uddevalla, Sweden.
出版信息
BMC Emerg Med. 2021 Oct 30;21(1):127. doi: 10.1186/s12873-021-00519-y.
BACKGROUND
To identify amino acids that can predict risk of 90-day mortality in patients with acute dyspnea.
METHOD
Plasma levels of nine amino acids were analyzed 663 adult patients admitted to the Emergency Department (ED) with acute dyspnea. Cox proportional hazards models were used to examine the relation between amino acid levels and the risk of 90-day mortality.
RESULT
Eighty patients (12.1%) died within 90 days of admission. An "Amino Acid Mortality Risk Score" (AMRS), summing absolute plasma levels of glycine, phenylalanine and valine, demonstrated that among the patients belonging to quartile 1 (Q1) of the AMRS, only 4 patients died, compared to 44 patients in quartile 4. Using Q1 of the AMRS as reference, each increment of 1 SD in the AMRS was associated with a hazard ratio (HR) of 2.15 for 90-day mortality, and the HR was > 9 times higher in Q4.
CONCLUSION
Glycine, phenylalanine and valine are associated with a risk of 90-day mortality in patients admitted to the ED for acute dyspnea, suggesting that these amino acids may be useful in risk assessments.
背景
鉴定可预测急性呼吸困难患者 90 天死亡率风险的氨基酸。
方法
分析了 663 名因急性呼吸困难而入住急诊部的成年患者的 9 种氨基酸的血浆水平。使用 Cox 比例风险模型来检验氨基酸水平与 90 天死亡率风险之间的关系。
结果
80 名患者（12.1%）在入院后 90 天内死亡。“氨基酸死亡率风险评分”（AMRS）将甘氨酸、苯丙氨酸和缬氨酸的血浆水平绝对值相加，结果表明，在 AMRS 第 1 四分位数（Q1）的患者中，只有 4 名患者死亡，而在第 4 四分位数（Q4）的患者中则有 44 名患者死亡。以 AMRS 的 Q1 为参考，AMRS 每增加 1 个标准差，与 90 天死亡率的风险比（HR）为 2.15，而在 Q4 中 HR 则高出 9 倍以上。
结论
甘氨酸、苯丙氨酸和缬氨酸与急诊部因急性呼吸困难入院的患者 90 天死亡率的风险相关，这表明这些氨基酸可能有助于风险评估。
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