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共同动脉干修复:在选定的患者中,作为可行的替代策略的姑息性治疗和延迟矫正。

Repair of common arterial trunk: palliation and delayed correction as a viable alternative strategy in selected patients.

机构信息

Department of Pediatric Cardiac Surgery, University of Erlangen, Erlangen, Germany.

Department of Pediatric Cardiology, University of Erlangen, Erlangen, Germany.

出版信息

Eur J Cardiothorac Surg. 2022 Jun 15;62(1). doi: 10.1093/ejcts/ezab455.

Abstract

OBJECTIVES

Primary repair of common arterial trunk (CAT) is burdened by high mortality rates, especially in the presence of multiple risk factors. Timing, possible palliative methods, optimal management of associated cardiac lesions and handling of a poor preoperative state are still under discussion.

METHODS

We retrospectively analysed all patients who underwent surgery for CAT in our institution between 2008 and November 2020. We included 22 patients, 11 of whom received primary correction (PC) and 11 of whom underwent initial palliation by partial repair, leaving the ventricular septal defect open and connecting the right ventricle to the pulmonary arteries with a small valveless right ventricle-to-pulmonary artery conduit. A delayed correction (DC) was performed after 11.5 ± 3.6 months.

RESULTS

The overall operative mortality was 4.5%; 1 patient (affected by severe truncal valve stenosis and presenting in a poor state preoperatively) in the DC group died after palliation. The incidence of postoperative pulmonary hypertensive crisis was significantly higher in the PC group (P = 0.027). No patient from either group required postoperative extracorporeal support. Survival rates after 6 years differed slightly (PC group, 90%; DC group, 70%; log-rank = 0.270).

CONCLUSIONS

PC of CAT remains an optimal surgical approach for patients with an expected low mortality. However, our data support palliation and DC as a suitable alternative strategy, especially in the presence of significant risk factors like interrupted aortic arch, poor preoperative condition or complex surgical anatomy.

摘要

目的

共同动脉干(CAT)的一期修复存在较高的死亡率,尤其是在存在多种危险因素的情况下。手术时机、可能的姑息治疗方法、合并心脏畸形的最佳处理以及术前状态较差的处理等方面仍存在争议。

方法

我们回顾性分析了 2008 年至 2020 年 11 月期间在我院接受 CAT 手术的所有患者。共纳入 22 例患者,其中 11 例行一期根治术(PC),11 例行部分修复的初始姑息治疗,即保持室间隔缺损开放,用小无瓣右心室-肺动脉管道将右心室与肺动脉连接。11.5±3.6 个月后进行延迟根治术(DC)。

结果

总的手术死亡率为 4.5%;姑息治疗后,DC 组的 1 例(合并严重的干瓣狭窄,术前状态较差)患者死亡。PC 组术后发生肺动脉高压危象的发生率显著高于 DC 组(P=0.027)。两组均无患者需要术后体外循环支持。6 年后的生存率略有差异(PC 组 90%,DC 组 70%;log-rank=0.270)。

结论

对于预期死亡率较低的患者,CAT 的 PC 仍然是一种最佳的手术方法。然而,我们的数据支持姑息治疗和 DC 作为一种合适的替代策略,尤其是在存在主动脉弓中断、术前状态较差或复杂的手术解剖等显著危险因素的情况下。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab1d/9257668/9118986f2c88/ezab455f4.jpg

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