Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
Hunan Key Laboratory of Aging Biology, Xiangya Hospital, Central South University, Changsha, China.
J Cosmet Dermatol. 2022 Jul;21(7):3068-3077. doi: 10.1111/jocd.14556. Epub 2021 Oct 31.
No researches about the interaction among the risk factors for rosacea were conducted. Some studies prompted obesity and spicy food may have some common pathways.
To clarify the relationship between body mass index (BMI) and rosacea, and explore the interaction between BMI and spicy food consumption in rosacea.
This hospital-based case-control study enrolled 1347 rosacea patients and 1290 healthy subjects. The demographic data and clinical data were collected. The association between BMI and rosacea, and the relative excess risk due to interaction of BMI and spicy food consumption was calculated.
No interaction was found between underweight, overweight/obesity, and spicy food consumption with regard to the risk of rosacea, mild-to-moderate rosacea, papulopustular rosacea (PPR), or phymatous rosacea (PhR). And underweight and overweight/obesity were not significant associated with rosacea, mild-to-moderate rosacea, PPR, or PhR (p > 0.05). However, spicy food consumption was significantly interacted with underweight on the risk of erythematotelangiectatic rosacea (ETR), and with overweight/obesity on the risk of severe rosacea. Underweight was associated with increased risk of ETR (adjusted odds ratio [aOR] = 1.91, 95% confidence interval [CI]: 1.21, 3.03) among spicy no users, but the association was attenuated into insignificant level when mixed with spicy food factor (p > 0.05). Among moderated spicy food consumers, overweight/obesity was associated with decreased risk of severe rosacea (aOR = 0.70, 95% CI: 0.50, 0.98), but overweight/obesity was insignificant associated with severe rosacea among spicy no users and heavy spicy food consumers (p > 0.05).
Body weight status alone was not significantly associated with rosacea, but the interaction between body weight status and spicy food consumption is involved in the rosacea.
目前尚无关于酒渣鼻危险因素相互作用的研究。一些研究表明肥胖和辛辣食物可能存在一些共同的途径。
阐明体重指数（BMI）与酒渣鼻之间的关系，并探讨 BMI 与辛辣食物摄入在酒渣鼻中的相互作用。
本项基于医院的病例对照研究纳入了 1347 例酒渣鼻患者和 1290 例健康对照者。收集了人口统计学数据和临床数据。计算了 BMI 与酒渣鼻之间的关联，以及 BMI 和辛辣食物摄入的交互作用引起的相对超额风险。
无论消瘦、超重/肥胖和辛辣食物摄入如何，它们之间均未发现与酒渣鼻、轻中度酒渣鼻、丘疹脓疱型酒渣鼻（PPR）或鼻赘型酒渣鼻（PhR）的风险相关。消瘦和超重/肥胖与酒渣鼻、轻中度酒渣鼻、PPR 或 PhR 无显著相关性（p＞0.05）。然而，辛辣食物摄入与消瘦者的红斑毛细血管扩张型酒渣鼻（ETR）风险显著相互作用，与超重/肥胖者的严重酒渣鼻风险显著相互作用。在不食用辛辣食物者中，消瘦与 ETR 风险增加相关（校正优势比[aOR]＝1.91，95％置信区间[CI]：1.21，3.03），但当与辛辣食物因素混合时，这种关联减弱至无统计学意义水平（p＞0.05）。在适度食用辛辣食物者中，超重/肥胖与严重酒渣鼻风险降低相关（aOR＝0.70，95％CI：0.50，0.98），但在不食用辛辣食物者和大量食用辛辣食物者中，超重/肥胖与严重酒渣鼻无显著相关性（p＞0.05）。
体重状况本身与酒渣鼻无显著相关性，但体重状况与辛辣食物摄入的相互作用与酒渣鼻有关。
