Li Zhengyi, Yang Song, Li Hu
State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, State-Local Joint Laboratory for Comprehensive Utilization of Biomass, Center for RD of Fine Chemicals, Guizhou University, Guiyang, 550025, Guizhou, China.
State Key Laboratory Breeding Base of Green Pesticide & Agricultural Bioengineering, Key Laboratory of Green Pesticide & Agricultural Bioengineering, Ministry of Education, State-Local Joint Laboratory for Comprehensive Utilization of Biomass, Center for R&D of Fine Chemicals, Guizhou University, Guiyang550025, Guizhou,China.
Curr Org Synth. 2022 Mar 3;19(2):187-196. doi: 10.2174/1570179418666211022160149.
The development of new sustainable catalytic conversion methods of carbon dioxide (CO) is of great interest in the synthesis of valuable chemicals. N-formylation of CO with amine nucleophiles as substrates has been studied in depth. The key to benign formylation is to select a suitable reducing agent to activate CO. This paper showcases the activation modes of CO and the construction strategies of sustainable and catalyst-free N-formylation systems. The research progress of catalyst-free N-formylation of amines and CO is reviewed. There are two broad prominent categories, namely reductive amidation of CO facilitated by organic solvents and ionic liquids in the presence of hydrosilane. Attention is also paid to discussing the involved reaction mechanism with practical applications and identifying the remaining challenges in this field.
二氧化碳（CO）新型可持续催化转化方法的开发在合成有价值化学品方面备受关注。以胺亲核试剂为底物对CO进行N-甲酰化反应已得到深入研究。良性甲酰化的关键在于选择合适的还原剂来活化CO。本文展示了CO的活化模式以及可持续且无催化剂的N-甲酰化体系的构建策略。综述了胺与CO无催化剂N-甲酰化的研究进展。主要有两大类显著的情况，即在硅烷存在下由有机溶剂和离子液体促进的CO还原酰胺化反应。同时也关注讨论所涉及的反应机理及其实际应用，并指出该领域尚存的挑战。
