Institute for Frontier Materials, Deakin University, Geelong, Victoria 3216, Australia.
ACS Biomater Sci Eng. 2021 Dec 13;7(12):5555-5572. doi: 10.1021/acsbiomaterials.1c00763. Epub 2021 Nov 1.
A series of quaternary Zn-Al-Cu-Li alloys with different weight fractions of Cu, Al, and Li were developed and investigated for potential application in high load bearing bioresorbable implants. The developed alloys provided various fractions of binary and ternary intermetallic structures, which resulted in formation of multiphase microstructures containing a zinc-rich η-phase and LiZn and CuZn phases. The intermetallic phases promoted grain refinement and a good combination of mechanical properties. The developed Zn-2Al-4Cu-0.6Li alloy showed strength and ductility close to commercially pure Ti alloys with a UTS value of ∼535 MPa and elongation of 37%. The examination of in vitro corrosion behavior of the developed alloys in the modified Hanks' solution revealed suitable corrosion rates (∼38.5 μm/year). The moderate corrosion rate was controlled by the formation of a homogeneous layer of stable corrosion products that protected the alloys from the corrosive environment, particularly in the late stages of immersion. The developed alloys with the most promising mechanical and corrosion properties appeared to be biocompatible to mouse fibroblast cells and human umbilical mesenchymal stem cells, making them suitable candidates for implant applications.
开发了一系列具有不同铜、铝和锂重量分数的四元 Zn-Al-Cu-Li 合金，并对其进行了研究，以期将其潜在应用于高负荷生物可吸收植入物。所开发的合金提供了各种二元和三元金属间化合物结构的分数，从而形成了包含富锌 η 相和 LiZn 和 CuZn 相的多相微观结构。金属间化合物相促进了晶粒细化和机械性能的良好结合。所开发的 Zn-2Al-4Cu-0.6Li 合金表现出接近纯商业钛合金的强度和延展性，其 UTS 值约为 535 MPa，伸长率为 37%。在改良的 Hank's 溶液中对所开发合金的体外腐蚀行为的检查表明，具有合适的腐蚀速率（约 38.5 μm/年）。适中的腐蚀速率受稳定腐蚀产物均匀层的形成控制，该层可保护合金免受腐蚀性环境的影响，特别是在浸泡的后期阶段。具有最有前途的机械和腐蚀性能的开发合金似乎对小鼠成纤维细胞和人脐带间充质干细胞具有生物相容性，使其成为植入物应用的合适候选物。
