Fu Fenfen, Zhang Yonghui, Sun Jie, Zhang Chun, Zhang Dongjie, Xie Lingduo, Chu Futao, Yu Xue, Xie Yuntao
Department of Breast Surgery, 594822Peking University International Hospital, Beijing, PR China.
Familial & Hereditary Cancer Center, 12519Peking University Cancer Hospital & Institute, Beijing, PR China.
Acta Radiol. 2022 Nov;63(11):1463-1468. doi: 10.1177/02841851211054191. Epub 2021 Oct 30.
The clinicopathological predictors of sentinel lymph node (SLN) metastasis in clinical T1-T2 N0 (cT1-T2 N0) patients with a normal axillary ultrasound (AUS) are unclear.
To assess the association between clinicopathological characteristics of a primary tumor and SLN metastasis in cT1-T2 N0 patients with a normal AUS.
Patients who were diagnosed with cT1-T2 N0 invasive breast cancer and who obtained normal AUS results between October 2016 and September 2018 in a single hospital were included. Clinicopathological data were collected to explore the predictors of SLN metastasis using a multivariate logistic regression model.
SLN metastasis occurred in 26 patients (18.4%) among 141 AUS-normal patients, of which 24 cases (17.0%) had one or two nodal involvements. In the univariate analysis, tumor location, estrogen receptor (ER) status, progesterone receptor (PR) status, and lymphovascular invasion (LVI) were significantly associated with SLN metastasis (< 0.05). The multivariate analysis showed that tumor location in the upper outer quadrant (odds ratio [OR] = 4.49, 95% confidence interval [CI] = 1.63-12.37; = 0.004), positive PR status (OR = 13.35, 95% CI = 1.60-111.39; = 0.017), and positive LVI (OR = 8.66, 95% CI = 2.20-34.18; = 0.002) were independent high-risk factors for SLN metastasis. The area under the receiver operating characteristic curve of the regression model was 0.787 (95% CI = 0.694-0.881; < 0.001).
Tumor location in the upper outer quadrant, positive PR, and LVI status were found to be significantly high-risk factors for SLN metastasis among cT1-T2 N0 breast cancer patients with a normal AUS result.
对于腋窝超声（AUS）结果正常的临床T1 - T2 N0（cT1 - T2 N0）患者，前哨淋巴结（SLN）转移的临床病理预测因素尚不清楚。
评估AUS结果正常的cT1 - T2 N0患者中原发肿瘤的临床病理特征与SLN转移之间的关联。
纳入2016年10月至2018年9月期间在一家医院被诊断为cT1 - T2 N0浸润性乳腺癌且AUS结果正常的患者。收集临床病理数据，使用多因素逻辑回归模型探索SLN转移的预测因素。
141例AUS结果正常的患者中有26例（18.4%）发生SLN转移，其中24例（17.0%）有一个或两个淋巴结受累。单因素分析显示，肿瘤位置、雌激素受体（ER）状态、孕激素受体（PR）状态和淋巴管浸润（LVI）与SLN转移显著相关（<0.05）。多因素分析表明，外上象限肿瘤位置（比值比[OR]=4.49，95%置信区间[CI]=1.63 - 12.37；P = 0.
