Fehr Célina Alexandra, Went Philip, Maranta Martina, Cathomas Richard
Department of Internal Medicine, Division of Oncology/Hematology, Cantonal Hospital of Graubünden, Chur, Switzerland.
Department of Pathology, Cantonal Hospital of Graubünden, Chur, Switzerland.
Breast Care (Basel). 2021 Oct;16(5):539-543. doi: 10.1159/000512975. Epub 2020 Dec 16.
Primary breast malignancy in adolescent women is very rare and differs in several aspects from findings in adult women.
A young woman aged 16 years presented with a locally aggressive breast tumor. The patient received cisplatin-based chemotherapy followed by tumor resection assuming a diagnosis of germ cell tumor. Four months later, she developed locally recurrent disease and underwent a mastectomy. No definite diagnosis was agreed upon despite intensive pathological workup. Subsequent management consisted of follow-up only and the patient remains in complete remission 9 years later.
This case demonstrates the difficulty of diagnosis and management of rare malignancies in adolescents, and highlights the importance of international and interdisciplinary collaboration in diagnosis and clinical decision-making.
青春期女性原发性乳腺癌非常罕见，在多个方面与成年女性的表现不同。
一名16岁年轻女性出现局部侵袭性乳腺肿瘤。患者接受了以顺铂为基础的化疗，随后进行肿瘤切除，初步诊断为生殖细胞肿瘤。四个月后，她出现局部复发性疾病并接受了乳房切除术。尽管进行了全面的病理检查，仍未达成明确诊断。后续治疗仅包括随访，9年后患者仍处于完全缓解状态。
该病例表明青少年罕见恶性肿瘤的诊断和治疗存在困难，并强调了国际和跨学科合作在诊断和临床决策中的重要性。
