Mangano Giuseppa Renata, Oliveri Massimiliano, Smirni Daniela, Tarantino Vincenza, Turriziani Patrizia
Department of Psychology, Educational Science and Human Movement, University of Palermo, Palermo, Italy.
Neuroteam Life and Science, Palermo, Italy.
Front Hum Neurosci. 2021 Oct 14;15:696793. doi: 10.3389/fnhum.2021.696793. eCollection 2021.
Neuroimaging, neuropsychological, and brain stimulation studies have led to contrasting findings regarding the potential roles of the lateral parietal lobe in episodic memory. Studies using brain stimulation methods reported in the literature do not offer unequivocal findings on the interactions with stimulation location (left vs. right hemisphere) or timing of the stimulation (encoding vs. retrieval). To address these issues, active and sham 1 Hz repetitive transcranial magnetic stimulation (rTMS) trains of 600 stimuli were applied over the right or left posterior parietal cortex (PPC) before the encoding or before the retrieval phase of a recognition memory task of unknown faces in a group of 40 healthy subjects. Active rTMS over the right but not the left PPC significantly improved non-verbal recognition memory performance without any significant modulation of speed of response when applied before the retrieval phase. In contrast, rTMS over the right or the left PPC before the encoding phase did not modulate memory performance. Our results support the hypothesis that the PPC plays a role in episodic memory retrieval that appears to be dependent on both the hemispheric lateralization and the timing of the stimulation (encoding vs. retrieval).
神经影像学、神经心理学和脑刺激研究对于顶叶外侧在情景记忆中的潜在作用得出了相互矛盾的结果。文献中报道的使用脑刺激方法的研究，在与刺激位置（左半球与右半球）或刺激时间（编码与提取）的相互作用方面，并未提供明确的结果。为了解决这些问题，在一组40名健康受试者对陌生面孔的识别记忆任务的编码阶段或提取阶段之前，在右侧或左侧顶叶后皮质（PPC）施加了600次刺激的1赫兹主动和伪重复经颅磁刺激（rTMS）序列。在提取阶段之前施加时，右侧而非左侧PPC上的主动rTMS显著提高了非言语识别记忆表现，而对反应速度没有任何显著调节。相比之下，在编码阶段之前对右侧或左侧PPC进行rTMS并未调节记忆表现。我们的结果支持这样的假设，即PPC在情景记忆提取中发挥作用，这似乎取决于半球侧化和刺激时间（编码与提取）。
