Department of Urology, Tianjin Medical University General Hospital, Tianjin, China.
Dis Markers. 2021 Oct 22;2021:9948241. doi: 10.1155/2021/9948241. eCollection 2021.
Dead end 1 (DND1) plays a vital role during oncogenesis and cancer progression by regulating the mRNA content via competitive combination with miRNA, but what function it exerts in prostate cancer has been unclear. The purpose of this paper is to explore the correlation between DND1 expression levels and clinical characteristics in prostate cancer (PCa) patients.
To assess the expression of DND1 in tumor specimens compared with paired paracancerous tissues, the sample from 83 patients was analyzed by immunohistochemistry. The Cancer Genome Atlas (TCGA) database was used to verify our results. Subsequently, we statistically analyzed the relationship between DND1 expression and the clinical prognosis of PCa patients.
Compared with paracancerous tissues, DND1 has a higher expression level in prostate cancer. The overexpression of DND1 in protein level was significantly associated with the higher clinical stage ( = 0.006), ISUP grading group ( < 0.001), seminal vesicle invasion ( = 0.006), and PSA density ( = 0.002). Furthermore, the overexpression of DND1 indicates a poor clinical prognosis in prostate cancer patients.
High-level expression of DND1 was associated with tumor progression and poor clinical prognosis. Hence, DND1 may become a potential prognostic biomarker for PCa.
通过与 miRNA 竞争结合来调节 mRNA 含量，终止子 1（DND1）在致癌和癌症进展中起着至关重要的作用，但它在前列腺癌中发挥什么功能尚不清楚。本文旨在探讨 DND1 表达水平与前列腺癌（PCa）患者临床特征之间的相关性。
为了评估肿瘤标本中 DND1 的表达与配对癌旁组织的比较，我们通过免疫组织化学分析了 83 例患者的样本。使用癌症基因组图谱（TCGA）数据库验证了我们的结果。随后，我们对 DND1 表达与 PCa 患者临床预后的关系进行了统计学分析。
与癌旁组织相比，DND1 在前列腺癌中的表达水平更高。DND1 蛋白水平的过表达与较高的临床分期（=0.006）、ISUP 分级组（<0.001）、精囊侵犯（=0.006）和 PSA 密度（=0.002）显著相关。此外，DND1 的过表达表明前列腺癌患者的临床预后不良。
高水平的 DND1 表达与肿瘤进展和不良的临床预后相关。因此，DND1 可能成为 PCa 的一个潜在预后生物标志物。
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