RNA 结合蛋白与 RNA 的相互作用：分子与机制。
How RNA-Binding Proteins Interact with RNA: Molecules and Mechanisms.
机构信息
Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA; Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA, USA.
出版信息
Mol Cell. 2020 Apr 2;78(1):9-29. doi: 10.1016/j.molcel.2020.03.011.
RNA-binding proteins (RBPs) comprise a large class of over 2,000 proteins that interact with transcripts in all manner of RNA-driven processes. The structures and mechanisms that RBPs use to bind and regulate RNA are incredibly diverse. In this review, we take a look at the components of protein-RNA interaction, from the molecular level to multi-component interaction. We first summarize what is known about protein-RNA molecular interactions based on analyses of solved structures. We additionally describe software currently available for predicting protein-RNA interaction and other resources useful for the study of RBPs. We then review the structure and function of seventeen known RNA-binding domains and analyze the hydrogen bonds adopted by protein-RNA structures on a domain-by-domain basis. We conclude with a summary of the higher-level mechanisms that regulate protein-RNA interactions.
RNA 结合蛋白（RBPs）是一大类超过 2000 种的蛋白质，它们以各种方式与 RNA 驱动的过程中的转录本相互作用。RBP 用于结合和调节 RNA 的结构和机制非常多样化。在这篇综述中，我们从分子水平到多组分相互作用，来探讨蛋白-RNA 相互作用的组成部分。我们首先根据已解决结构的分析，总结了已知的蛋白-RNA 分子相互作用。此外，我们还描述了当前可用于预测蛋白-RNA 相互作用的软件和其他对 RBPs 研究有用的资源。然后，我们回顾了十七种已知 RNA 结合结构域的结构和功能，并分析了基于域的蛋白-RNA 结构采用的氢键。最后，我们总结了调节蛋白-RNA 相互作用的更高层次的机制。
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