Nakamura Misa, Imaoka Masakazu, Hashizume Hiroshi, Tazaki Fumie, Hida Mitsumasa, Nakao Hidetoshi, Omizu Tomoko, Kanemoto Hideki, Takeda Masatoshi
Cognitive Reserve Research Center, Osaka Kawasaki Rehabilitation University, Kaizuka, Osaka, Japan.
Department of Rehabilitation, Osaka Kawasaki Rehabilitation University, Kaizuka, Osaka, Japan.
PeerJ. 2021 Oct 15;9:e12292. doi: 10.7717/peerj.12292. eCollection 2021.
Cognitive decline is closely related to motor decline. Locomotive syndrome (LS) is defined as a state associated with a high risk of requiring support because of locomotive organ disorders, and can be evaluated using a questionnaire. This study aimed to clarify the effectiveness of daily goal-targeted exercise on cognitive function in two different populations classified by scores on the Locomo 25 questionnaire.
Seventy community-dwelling older people who participated in a 13-week health class were divided into two populations based on Locomo 25 scores: <7 (non-LS) and ≥7 (LS). Participants were presented with a daily target steps and worked towards that goal. Cognitive function was evaluated using the Japanese version of Addenbrooke's Cognitive Examination-Revised (ACE-R). Average daily physical activity (exercise [Ex]) for 13 weeks was measured using a portable activity meter. Depression status was assessed using the Geriatric Depression Scale (GDS-15).
No significant differences were observed in age, years of education, body mass index, smooth muscle mass index, GDS-15 scores, or ACE-R scores between the non-LS and LS populations. Multiple logistic regression analysis showed that Ex (odds ratio = 5.01, = 0.002) for 13 weeks was significantly associated with increased cognitive function in the LS population. The Ex threshold for the increase in cognitive function based on receiver operating curve analysis was 2.29 metabolic equivalents of task (METs) × h (METs · h/day) ( = 0.047) in the LS population. After 13 weeks, ACE-R scores were significantly higher in the Ex ≥ 2.29 than in the Ex < 2.29 METs · h/day group ( = 0.024, η = 0.241) in the LS population based on two-way analysis of covariance. Furthermore, a significant increase in the ACE-R memory domain was seen in the Ex ≥ 2.29 group ( = 0.035, η = 0.213).
These results suggest that Ex ≥ 2.29 METs · h/day is important for improving cognitive function in LS populations.
认知功能衰退与运动功能衰退密切相关。运动机能不全综合征（LS）被定义为一种因运动器官功能障碍而需要他人支持的高风险状态，可通过问卷调查进行评估。本研究旨在明确针对日常目标的锻炼对根据Locomo 25问卷得分划分的两类不同人群认知功能的有效性。
70名参加为期13周健康课程的社区老年人根据Locomo 25得分被分为两组：<7分（非LS组）和≥7分（LS组）。为参与者设定每日目标步数，并朝着该目标努力。使用日本版修订版Addenbrooke认知检查（ACE-R）评估认知功能。使用便携式活动计测量13周内的平均每日身体活动量（锻炼[Ex]）。使用老年抑郁量表（GDS-15）评估抑郁状态。
非LS组和LS组在年龄、受教育年限、体重指数、平滑肌质量指数、GDS-15得分或ACE-R得分方面未观察到显著差异。多元逻辑回归分析显示，13周的锻炼（Ex）（比值比=5.01，P=0.002）与LS组认知功能增强显著相关。基于受试者工作特征曲线分析，LS组认知功能增强的锻炼阈值为2.29代谢当量任务（METs）×小时（METs·小时/天）（P=0.047）。基于双向协方差分析，13周后，LS组中锻炼量≥2.29 METs·小时/天的组的ACE-R得分显著高于锻炼量<2.29 METs·小时/天的组（P=0.024，η²=0.241）。此外，锻炼量≥2.29 METs·小时/天的组的ACE-R记忆领域有显著增加（P=0.035，η²=0.213）。
这些结果表明，锻炼量≥2.29 METs·小时/天对改善LS人群的认知功能很重要。
