印度尼西亚西爪哇一家三级医院治疗的视网膜母细胞瘤的高风险组织病理学特征。
High-Risk Histopathologic Features of Retinoblastoma Treated at a Tertiary Hospital in West Java, Indonesia.
作者信息
Sari Nur Melani, Hadiputri Regina, Kuntorini Maya Sari, Agustina Hasrayati, Mardianty Friska
机构信息
Department of Child Health, Dr. Hasan Sadikin Hospital/Universitas Padjadjaran, Bandung, Indonesia.
Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.
出版信息
Ocul Oncol Pathol. 2021 Oct;7(5):353-360. doi: 10.1159/000517100. Epub 2021 Jul 20.
PURPOSE
To evaluate the histopathological characteristics of clinically advanced retinoblastoma (RB) and its relationship with tumor differentiation.
METHODS
This was a cross-sectional study of primary enucleated group D/E intraocular RB using medical records from 2017 to 2020 in a tertiary referral hospital. Cases with incomplete histopathological results were excluded. Tumors were classified into well, moderately, and poorly differentiated and undifferentiated. High-risk histopathological features were classified as per Thaung and Karaa [. 2018;31(101):17-3].
RESULTS
This study included 121 patients (129 eyes), of which 32.2% were diagnosed at 25-36 months. High-risk features (HRFs) were found in 100/129 eyes, and of 73 complete histopathological results, the 2 most common HRFs were postlaminar optic nerve invasion and massive choroidal invasion. RB was poorly differentiated in 69.9% and well differentiated in 12.3% of eyes. There was no statistically significant association between any HRFs and tumor differentiation, with age >2 years associated with tumor differentiation ( < 0.05).
CONCLUSION
The frequency of HRFs is 77.5% of primary enucleated eyes, mainly poorly and undifferentiated cells, particularly in children aged >2 years old.
目的
评估临床晚期视网膜母细胞瘤（RB）的组织病理学特征及其与肿瘤分化的关系。
方法
这是一项对2017年至2020年在一家三级转诊医院接受原发性眼球摘除的D/E期眼内RB患者进行的横断面研究。排除组织病理学结果不完整的病例。肿瘤分为高分化、中分化、低分化和未分化。根据Thaung和Karaa[2018;31(101):17 - 3]对高风险组织病理学特征进行分类。
结果
本研究纳入121例患者（129只眼），其中32.2%在25 - 36个月时被诊断。在129只眼中，100只发现高风险特征（HRFs），在73份完整的组织病理学结果中，2种最常见的HRFs是层后视神经侵犯和脉络膜大面积侵犯。69.9%的眼RB为低分化，12.3%为高分化。任何HRFs与肿瘤分化之间均无统计学显著关联，年龄>2岁与肿瘤分化相关（P<0.05）。
结论
HRFs在原发性眼球摘除眼中的发生率为77.5%，主要为低分化和未分化细胞，尤其是在年龄>2岁的儿童中。
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