Wood Christopher, Balciunas Mindaugas, Lordan Jim, Mellor Adrian
James Cook University Hospital, Middlesbrough, UK.
Newcastle Upon Tyne Hospitals NHS Foundation Trust, Tyne, England.
J Crit Care Med (Targu Mures). 2021 May 12;7(2):83-96. doi: 10.2478/jccm-2021-0007. eCollection 2021 Apr.
Pulmonary hypertension is a rare and progressive pathology defined by abnormally high pulmonary artery pressure mediated by a diverse range of aetiologies. It affects up to twenty-six individuals per one million patients currently living in the United Kingdom (UK), with a median life expectancy of 2.8 years in idiopathic pulmonary hypertension. The diagnosis of pulmonary hypertension is often delayed due to the presentation of non-specific symptoms, leading to a delay in referral to specialists services. The complexity of treatment necessitates a multidisciplinary approach, underpinned by a diverse disease aetiology from managing the underlying disease process to novel specialist treatments. This has led to the formation of dedicated specialist treatment centres within centralised UK cities. The article aimed to provide a concise overview of pulmonary hypertension's clinical perioperative management, including key definitions, epidemiology, pathophysiology, and risk stratification.
肺动脉高压是一种罕见的进行性疾病,由多种病因介导的异常高的肺动脉压力所定义。目前生活在英国的每百万患者中,多达26人受其影响,特发性肺动脉高压患者的中位预期寿命为2.8年。由于非特异性症状的出现,肺动脉高压的诊断常常延迟,导致转诊至专科服务的延迟。治疗的复杂性需要多学科方法,这基于从管理潜在疾病过程到新型专科治疗的多种疾病病因。这导致在英国中部城市形成了专门的专科治疗中心。本文旨在简要概述肺动脉高压的临床围手术期管理,包括关键定义、流行病学、病理生理学和风险分层。