Dey Raghunath, Nayak Sourav, Das Parthasarathi, Yadav Somnath
Department of Chemistry, Indian Institute of Technology (ISM), Dhanbad 826004, Jharkhand, India.
ACS Omega. 2021 Oct 11;6(42):28366-28372. doi: 10.1021/acsomega.1c04550. eCollection 2021 Oct 26.
Molnupiravir (MK-4482, EIDD-2801) is an experimental drug that has been demonstrated to be effective for the treatment of COVID-19 in human clinical trials. Herein, we report a concise synthesis of the drug a novel thionated derivative that relies on one-pot methodologies, thus decreasing the number of purification steps required. This route provides the drug in an overall 62% yield and >99% purity and uses cheap and readily available bulk chemicals, thereby providing an affordable synthesis of the drug for cheaper and wider global accessibility.
莫努匹拉韦（MK-4482，EIDD-2801）是一种实验性药物，已在人体临床试验中证明对治疗新冠肺炎有效。在此，我们报告了该药物的一种简洁合成方法——一种依赖一锅法的新型硫代衍生物，从而减少了所需的纯化步骤。该路线以62%的总收率和>99%的纯度提供该药物，并使用廉价且易于获得的大宗化学品，从而为更便宜、更广泛的全球可及性提供了一种经济实惠的药物合成方法。
