Kozani Pooria Safarzadeh, Kozani Pouya Safarzadeh, Malik Mohammad Tariq
Carlos Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran 14115/111, Iran.
Department of Medical Biotechnology, Faculty of Paramedicine, Guilan University of Medical Sciences, Rasht 41446/66949, Iran.
Explor Med. 2021;2:146-166. doi: 10.37349/emed.2021.00039. Epub 2021 Apr 30.
Nucleolin (NCL) is a multifunctional nucleolar phosphoprotein harboring critical roles in cells such as cell proliferation, survival, and growth. The dysregulation and overexpression of NCL are related to various pathologic and oncological indications. These characteristics of NCL make it an ideal target for the treatment of various cancers. AS1411 is a synthetic quadruplex-forming nuclease-resistant DNA oligonucleotide aptamer which shows a considerably high affinity for NCL, therefore, being capable of inducing growth inhibition in a variety of tumor cells. The high affinity and specificity of AS1411 towards NCL make it a suitable targeting tool, which can be used for the functionalization of therapeutic payloaddelivery nanosystems to selectively target tumor cells. This review explores the advances in NCL-targeting cancer therapy through AS1411-functionalized delivery nanosystems for the selective delivery of a broad spectrum of therapeutic agents.
核仁素（NCL）是一种多功能核仁磷蛋白，在细胞增殖、存活和生长等方面发挥着关键作用。NCL的失调和过表达与多种病理和肿瘤学指征相关。NCL的这些特性使其成为治疗各种癌症的理想靶点。AS1411是一种合成的形成四链体的耐核酸酶DNA寡核苷酸适配体，对NCL具有相当高的亲和力，因此能够在多种肿瘤细胞中诱导生长抑制。AS1411对NCL的高亲和力和特异性使其成为一种合适的靶向工具，可用于治疗有效载荷递送纳米系统的功能化，以选择性地靶向肿瘤细胞。本综述探讨了通过AS1411功能化递送纳米系统进行NCL靶向癌症治疗的进展，以实现多种治疗剂的选择性递送。
