BGI College, Zhengzhou University, Zhengzhou, Henan, China.
Henan Institute of Medical and Pharmaceutical Science, Zhengzhou University, Zhengzhou, Henan, China.
Int J Cancer. 2022 Apr 15;150(8):1223-1232. doi: 10.1002/ijc.33863. Epub 2021 Nov 9.
Tumor blood vessels provide oxygen and necessary nutrients for the tumor, which provides the basis for tumor metastasis. Therefore, tumor angiogenesis plays a very important role in tumor growth and metastasis. In contrast to linear RNAs, circRNAs represent a type of closed-loop RNA with diverse biological functions. At the same time, circRNAs have strong stability, timeliness, tissue specificity and disease specificity. With the rapid development of next-generation sequencing and bioinformatics, there have been an increasing number of studies on circRNAs. At present, a large number of studies have reported that circRNAs regulate tumor growth, invasion, metastasis, tumor metabolism, tumor immunity and other biological functions. Increasing evidence has shown that circRNAs also play an important role in tumor angiogenesis. In this review, we briefly introduced tumor angiogenesis and circRNAs and outlined the main ways that circRNAs affect tumor angiogenesis from multiple aspects. Finally, we further explored the potential clinical application value of circRNAs in the context of tumor angiogenesis.
肿瘤血管为肿瘤提供氧气和必要的营养物质，这为肿瘤转移提供了基础。因此，肿瘤血管生成在肿瘤生长和转移中起着非常重要的作用。与线性 RNA 不同，circRNA 是一种具有多种生物学功能的闭环 RNA。同时，circRNA 具有很强的稳定性、时效性、组织特异性和疾病特异性。随着下一代测序和生物信息学的快速发展，circRNA 的研究越来越多。目前，大量研究报道 circRNA 调节肿瘤生长、侵袭、转移、肿瘤代谢、肿瘤免疫等生物学功能。越来越多的证据表明，circRNA 也在肿瘤血管生成中发挥重要作用。在这篇综述中，我们简要介绍了肿瘤血管生成和 circRNA，并从多个方面概述了 circRNA 影响肿瘤血管生成的主要途径。最后，我们进一步探讨了 circRNA 在肿瘤血管生成背景下的潜在临床应用价值。
