Omvik P, Lund-Johansen P
Acta Med Scand Suppl. 1986;714:71-4. doi: 10.1111/j.0954-6820.1986.tb08971.x.
During moderate sodium restriction for 9 months in 19 men (33 years) with previously untreated mild essential hypertension (EH) sodium excretion fell from 209 to 139 mmol/24 h. Concomitantly intraarterial pressure at rest sitting fell from 145/93 to 138/88 mmHg (5%) and during 100 W exercise from 168/90 to 162/86 mmHg (4%). The fall in BP was due to reduction in cardiac output (5-11% at rest and during exercise) while peripheral vascular resistance was raised (4-10%). Thus, moderate sodium restriction was not very efficient treatment in our patients with mild EH. The main hemodynamic disturbance of established EH--an increase in vascular resistance--was not normalized after 9 months of low salt diet.
对19名（33岁）未经治疗的轻度原发性高血压（EH）男性进行为期9个月的适度钠限制期间，钠排泄量从209 mmol/24小时降至139 mmol/24小时。与此同时，静息坐位时的动脉内压从145/93 mmHg降至138/88 mmHg（5%），在100 W运动期间从168/90 mmHg降至162/86 mmHg（4%）。血压下降是由于心输出量减少（静息和运动时减少5 - 11%），而外周血管阻力升高（4 - 10%）。因此，适度钠限制对我们的轻度EH患者并非非常有效的治疗方法。已确诊的EH的主要血流动力学紊乱——血管阻力增加——在低盐饮食9个月后并未恢复正常。
