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肛裂切除术与侧方内括约肌切开术治疗慢性肛裂的随机对照试验

Fissurectomy Versus Lateral Internal Sphincterotomy in the Treatment of Chronic Anal Fissure: A Randomized Control Trial.

作者信息

Bara Bipin Kishore, Mohanty Sujit Kumar, Behera Satya Narayan, Sahoo Ashok Kumar, Swain Santanu Kumar

机构信息

Surgery, Santha Bhima Bhoi Medical College and Hospital, Balangir, IND.

Surgery, Srirama Chandra Bhanja Medical College and Hospital, Cuttack, IND.

出版信息

Cureus. 2021 Sep 28;13(9):e18363. doi: 10.7759/cureus.18363. eCollection 2021 Sep.

Abstract

Introduction An anal fissure is defined as a longitudinal split in the distal anoderm which extends from the anal verge to the dentate line. Fissures can be of primary or secondary type. The posterior midline is the most common location for primary fissures, while, anterior primary fissures, though rare, are more common in females. The cause of primary fissure is idiopathic. But secondary fissures are associated with other systemic diseases and can occur at an abnormal position anywhere in the anoderm. A high percentage of acute fissures heal spontaneously within three weeks with conservative medical management comprising of a high fiber diet, warm sitz bath, and topical analgesic with steroids. Secondary anal fissures will not heal in any form of treatment until the primary cause is addressed. These fissures often need surgical treatment. The lateral internal sphincterotomy (LIS) is one of the most practiced treatments for chronic anal fissure. Nonetheless, anal incontinence is one of the worrisome complications of LIS. Fissurectomy is one of the options among those techniques which address the issues with LIS. Some studies showed that patients with chronic fissures who are refractory to medical treatment responded well to fissurectomy. Hence, this study was conducted to compare the outcomes of fissurectomy and lateral internal sphincterotomy in the treatment of chronic anal fissure and compare recurrence and postoperative complications among both the procedures. Methods All consecutive patients attending the department of surgery with chronic fissure and age above 18 years were included in the study. All the included patients were randomized into two groups (fissurectomy and LIS) using the serially numbered opaque-sealed envelope (SNOSE) technique. The patients were discharged on the third day. The first visit was scheduled after two weeks and subsequent visits on the first and second months. Then the patients were followed up by telephonic conversation for the next six months. At the end of the follow-up, post-surgical complications were enquired, recorded, and interpreted. Results In the present study, out of a total of 87 patients, 80 patients were included in the study. Among all the patients, 16 patients (20%) developed retention of urine. Four patients in the LIS group showed retention of urine whereas in the fissurectomy group it was twelve. The difference was not statistically significant (p-value: 0.025). A total of 10 patients required catheterization postoperatively. More patients in the fissurectomy group developed incontinence to flatus (p-value: 0.02). Incontinence to liquid and solid was significantly higher in the fissurectomy group (p-value: 0.03 and 0.002, respectively). Conclusion In the present study, it was found that LIS was a better treatment option for chronic anal fissure than Fissurectomy. The postoperative complications were less in LIS than in fissurectomy. But the recurrence was higher in the LIS group while there was no recurrence in the fissurectomy group.

摘要

引言

肛裂被定义为远端肛管皮肤的纵向裂开,从肛缘延伸至齿状线。肛裂可分为原发性或继发性。原发性肛裂最常见于后正中线,而原发性前位肛裂虽罕见,但在女性中更常见。原发性肛裂的病因不明。但继发性肛裂与其他全身性疾病有关,可发生于肛管皮肤的任何异常位置。高比例的急性肛裂通过包括高纤维饮食、温水坐浴和局部使用含类固醇的镇痛药在内的保守药物治疗,在三周内可自愈。继发性肛裂在未解决其根本病因之前,任何形式的治疗都无法使其愈合。这些肛裂通常需要手术治疗。外侧内括约肌切断术(LIS)是治疗慢性肛裂最常用的方法之一。然而,肛门失禁是LIS令人担忧的并发症之一。肛裂切除术是解决LIS相关问题的技术之一。一些研究表明,对药物治疗无效的慢性肛裂患者对肛裂切除术反应良好。因此,本研究旨在比较肛裂切除术和外侧内括约肌切断术治疗慢性肛裂的效果,并比较两种手术的复发率和术后并发症。

方法

本研究纳入了所有年龄在18岁以上、因慢性肛裂到外科就诊的连续患者。所有纳入患者采用连续编号的不透光密封信封(SNOSE)技术随机分为两组(肛裂切除术组和LIS组)。患者在第三天出院。首次随访安排在两周后,随后在第一个月和第二个月进行随访。然后通过电话随访患者接下来的六个月。随访结束时,询问、记录并解释术后并发症情况。

结果

在本研究中,总共87例患者,80例被纳入研究。在所有患者中,16例(20%)出现尿潴留。LIS组有4例患者出现尿潴留,而肛裂切除术组有12例。差异无统计学意义(p值:0.025)。共有10例患者术后需要导尿。肛裂切除术组更多患者出现排气失禁(p值:0.02)。肛裂切除术组的液体和固体便失禁情况明显更高(p值分别为:0.03和0.002)。

结论

在本研究中,发现对于慢性肛裂,LIS比肛裂切除术是更好的治疗选择。LIS的术后并发症比肛裂切除术少。但LIS组的复发率更高,而肛裂切除术组无复发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e17/8555853/3ff446c4d512/cureus-0013-00000018363-i01.jpg

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