一个患有新生儿同种免疫性血小板减少症的家庭中主要组织相容性复合体的系谱。
Pedigree of the major histocompatibility complex in a family with a neonatal alloimmune thrombocytopenia.
作者信息
Panzer S, Kiefel V, Mayr W R, Fielder A H, Lachmann D, Mueller-Eckhardt C
出版信息
Biol Neonate. 1987;51(4):194-7. doi: 10.1159/000242651.
Immunization of a mother negative for the platelet-specific antigen P1A1 against the P1A1 antigen of her child induced neonatal alloimmune thrombocytopenia. This prompt immune response occurred in her first pregnancy and we were therefore interested to study whether there is an association with genes located within the major histocompatibility complex. We deduced haplotypes of HLA-A, B, C and DR as well as of complement C2, C4 and Bf in the maternal family members.
一位血小板特异性抗原P1A1阴性的母亲针对其孩子的P1A1抗原进行免疫接种后，引发了新生儿同种免疫性血小板减少症。这种迅速的免疫反应发生在她的首次妊娠中，因此我们有兴趣研究它是否与位于主要组织相容性复合体内的基因有关联。我们推断了母系家庭成员中HLA - A、B、C和DR以及补体C2、C4和Bf的单倍型。
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