School of Nursing, University of North Carolina at Chapel Hill, Chapel Hill (Drs Avorgbedor, Zou, and Yeo); School of Nursing, University of Wisconsin Milwaukee, Milwaukee (Dr Gondwe); and Health Sciences Library, University of North Carolina at Chapel Hill, Chapel Hill (Ms Conklin).
J Perinat Neonatal Nurs. 2021;35(4):E58-E68. doi: 10.1097/JPN.0000000000000603.
There is a lack of knowledge on the intersection between prematurity, small for gestational age, and hypertensive disorders of pregnancy (HDP). Therefore, the aim of this systematic review was to examine the outcomes of preterm infants who were small for gestational age born to women with HDP. Searches were conducted with no date restriction through the final search date of May 13, 2020, in the following databases: PubMed, Web of Science Core Collection, Cumulative Index of Nursing and Allied Health Literature Plus with Full Text (EBSCOhost), and Embase (Elsevier). A total of 6 studies were eligible for this review. The adjusted odds of mortality and necrotizing enterocolitis were significantly lower in the pregnancy-induced hypertension (PIH)/HDP group than in the non-PIH/HDP group. There was no significant difference in the odds of respiratory distress syndrome, bronchopulmonary dysplasia, and intraventricular hemorrhage between PIH/HDP and non-PIH/HDP groups. There was no significant difference between PIH/HDP and non-PIH/HDP groups in cystic periventricular leukomalacia, retinopathy of prematurity, late-onset sepsis, patent ductus arteriosus, length of hospital stays, duration of supplemental oxygen use, duration of mechanical ventilation, and continuous airway pressure. The studies included in this systematic review demonstrated that PIH/HDP is associated with lower infant mortality and necrotizing enterocolitis.
目前，人们对于早产、小于胎龄儿和妊娠高血压疾病（HDP）之间的关系知之甚少。因此，本系统评价的目的在于研究患有 HDP 的女性所生的小于胎龄儿早产儿的结局。本次检索没有设定时间限制，截至 2020 年 5 月 13 日，检索了以下数据库：PubMed、Web of Science 核心合集、Cumulative Index of Nursing and Allied Health Literature Plus with Full Text（EBSCOhost）和 Embase（Elsevier）。共有 6 项研究符合本次评价的纳入标准。与非妊娠高血压/ HDP 组相比，妊娠高血压（PIH）/ HDP 组的婴儿死亡率和坏死性小肠结肠炎的调整后比值比显著降低。PIH/ HDP 组与非 PIH/ HDP 组在呼吸窘迫综合征、支气管肺发育不良和脑室内出血的比值比方面没有显著差异。PIH/ HDP 组与非 PIH/ HDP 组在囊性脑室周围白质软化、早产儿视网膜病变、晚发性败血症、动脉导管未闭、住院时间、补充氧使用时间、机械通气时间和持续气道正压方面没有显著差异。本次系统评价纳入的研究表明，PIH/ HDP 与婴儿死亡率和坏死性小肠结肠炎降低相关。
