Khan Fiza M, Tran Andrew, Wong Philip Kin-Wai, Aiyedipe Samuel, Loya Mohammed F, Cristescu Mircea M, Gonzalez Felix M
Department of Diagnostic and Interventional Radiology, Emory University School of Medicine, 1364 Clifton Road NE, Atlanta, GA, 30322, USA.
Emory University School of Medicine, Atlanta, GA, USA.
Skeletal Radiol. 2022 Jun;51(6):1215-1223. doi: 10.1007/s00256-021-03944-z. Epub 2021 Nov 2.
The objective of this study is to introduce cooled radiofrequency ablation technical feasibility as an alternative percutaneous image-guided treatment of chronic pain and stiffness in the setting of uncomplicated total knee arthroplasty.
This retrospective pilot study includes a total of 19 consecutive patients experiencing persistent chronic pain after total knee arthroplasty, without underlying hardware complications who had failed conservative care. Patients initially underwent anesthetic blocks of the genicular nerve branches to determine C-RFA candidacy. After adequate response to the anesthetic blocks (> 50% immediate pain relief), patients were subjected to cooled radiofrequency ablations 2-3 weeks later. Treatment response was evaluated utilizing clinically validated questionnaires (KOOS, the Knee Injury and Osteoarthritis Outcome Score) and visual analog scale (VAS) to assess pain severity, stiffness, functional activities of daily living, and use of pain medication. Follow-up outcome scores were collected up to 1 year after C-RFA procedure.
A total of 21 knees were treated consecutively between 4/2019 and 1/2020 (mean age 70.5 years; 5 M:14F). The mean total KOOS score improved significantly from baseline at 35.0 ± 14.0 to 64.2 ± 14.7 at a mean of 10.2 months after treatment (p < 0.0001), with significant improvement in mean stiffness score from 44.8 ± 16.7 to 68.8 ± 20 (p < 0.0001). The mean VAS score improved significantly from baseline at 8.30 ± 1.1 to 2.45 ± 1.8 (p < 0.0001). No major complications were encountered. No patients went on to receive re-treatment, surgical revision, or other intervention.
Image-guided genicular nerve cooled radiofrequency ablation offers a promising alternative in treating chronic pain/stiffness in the setting of uncomplicated TKA.
本研究的目的是介绍冷循环射频消融术作为一种经皮影像引导下治疗全膝关节置换术后慢性疼痛和僵硬的替代方法的技术可行性。
这项回顾性试点研究共纳入19例全膝关节置换术后持续存在慢性疼痛且无潜在硬件并发症且保守治疗无效的连续患者。患者最初接受膝神经分支的麻醉阻滞以确定是否适合冷循环射频消融术。在对麻醉阻滞有充分反应(即时疼痛缓解>50%)后,患者在2至3周后接受冷循环射频消融术。利用经过临床验证的问卷(KOOS,膝关节损伤和骨关节炎结果评分)和视觉模拟量表(VAS)评估治疗反应,以评估疼痛严重程度、僵硬程度、日常生活功能活动以及止痛药物的使用情况。在冷循环射频消融术后1年内收集随访结果评分。
在2019年4月至2020年1月期间,共连续治疗了21个膝关节(平均年龄70.5岁;男性5例:女性14例)。平均总KOOS评分从基线时的35.0±14.0显著提高至治疗后平均10.2个月时的64.2±14.7(p<0.0001),平均僵硬评分从44.8±16.7显著提高至68.8±20(p<0.0001)。平均VAS评分从基线时的8.30±1.1显著提高至2.45±1.8(p<0.0001)。未出现重大并发症。没有患者继续接受再次治疗、手术翻修或其他干预。
影像引导下的膝神经冷循环射频消融术为治疗无并发症的全膝关节置换术后慢性疼痛/僵硬提供了一种有前景的替代方法。