Li J, Zhang J Q, Yao Y X, Lu X T, Song J, Niu Q, Wang L P
Department of Occupational Health, School of Public Health, Shanxi Medical University, Taiyuan 030001, China.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2021 Oct 20;39(10):748-751. doi: 10.3760/cma.j.cn121094-20200603-00315.
To explore the effect of occupational aluminum (Al) exposure on workers' overall cognitive level and speech function. In July 2019, by using cluster sampling method, the group of 232 exposed to Al from an Al plant in Shanxi Province were selected as the exposed group, and the group of 228 not exposed to Al were selected as the control group. The blood Al concentration was determined by inductively coupled plasma mass spectrometry (ICP-MAS) . The exposed group was divided into high exposure group and low exposure group according to the median () concentration of Al in serum. The general cognitive function and speech function were evaluated with the Montreal Cognitive Assessment Scale (MoCA) , and the differences in the general cognitive function and speech function between the groups were compared, and non-conditional logistic regression was used to analyze the possible influencing factors of mild cognitive impairment (MCI) . There were significant differences in age, working age, education and drinking status between Al exposed group and control group (<0.05) . The total MoCA score, animal naming tese (ANT) score and category fluency repetition (CFT) score in Al exposure group were lower than control group and the differences were statistically significant (<0.05) . The full rate of ANT was lower than that of CFT in Al exposure group (<0.05) . The total MoCA score, ANT score and CFT score in the high exposure group were significantly lower than those in the control group (<0.05) . The score of MoCA, ANT and CFT in high exposure group were lower than those in low exposure group between the level of serum aluminum>60 μg/L group and ≤60 μg/L group (<0.05) . Logistic regression analysis showed that working age, serun Al concentration, ANT score, CFT score and SR score were the possible influencing factors of MCI in occupational Al exposure workers (<0.05) . Occupational Al exposure can lead to impaired speech function of workers, the higher the ANT score, CFT score and SR score, the lower working age and serum Al concentration, the lower risk of MCI.
探讨职业性铝暴露对工人整体认知水平和言语功能的影响。2019年7月，采用整群抽样方法，选取山西省某铝厂232名铝暴露工人作为暴露组，选取228名未接触铝的工人作为对照组。采用电感耦合等离子体质谱法（ICP - MAS）测定血铝浓度。暴露组根据血清铝浓度中位数（）分为高暴露组和低暴露组。采用蒙特利尔认知评估量表（MoCA）评估一般认知功能和言语功能，比较各组一般认知功能和言语功能的差异，并采用非条件logistic回归分析轻度认知障碍（MCI）的可能影响因素。铝暴露组与对照组在年龄、工龄、文化程度和饮酒状况方面存在显著差异（<0.05）。铝暴露组MoCA总分、动物命名测试（ANT）得分和类别流畅性重复（CFT）得分均低于对照组，差异有统计学意义（<0.05）。铝暴露组ANT满分率低于CFT满分率（<0.05）。高暴露组MoCA总分、ANT得分和CFT得分均显著低于对照组（<0.05）。血清铝>60μg/L组与≤60μg/L组相比，高暴露组MoCA、ANT和CFT得分低于低暴露组（<0.05）。logistic回归分析显示，工龄、血清铝浓度、ANT得分、CFT得分和SR得分是职业性铝暴露工人MCI的可能影响因素（<0.05）。职业性铝暴露可导致工人言语功能受损，ANT得分、CFT得分和SR得分越高，工龄和血清铝浓度越低，MCI风险越低。
