Abstract
Retinoids are vitamin A derivatives that have therapeutic benefit in the treatment of hyperkeratotic genodermatosis, psoriasis, and acne. Isotretinoin (Accutane), a first-generation retinoid, is used in the treatment of cystic acne. Etretinate (Tegison), a second-generation retinoid, is used in the treatment of severe psoriasis. Third-generation drugs are currently being tested. Side effects and long-term toxicity are of concern. Etretinate in combination with ultraviolet B and psoralen-ultraviolet A (PUVA) is especially beneficial in the treatment of psoriasis.
摘要
维甲酸是维生素A的衍生物，在治疗角化过度性遗传性皮肤病、银屑病和痤疮方面具有治疗益处。第一代维甲酸异维A酸（泰尔丝）用于治疗囊肿性痤疮。第二代维甲酸阿维A酯（银屑灵）用于治疗重度银屑病。目前正在测试第三代药物。副作用和长期毒性令人担忧。阿维A酯与紫外线B及补骨脂素-紫外线A（PUVA）联合使用在治疗银屑病方面特别有效。
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