Eber J, Nannini S, Chambrelant I, Le Fèvre C, Noël G, Antoni D
Department of radiation oncology, institut de cancérologie Strasbourg Europe (ICANS), 17, rue Albert-Calmette, 67200 Strasbourg, France.
Department of radiation oncology, institut de cancérologie Strasbourg Europe (ICANS), 17, rue Albert-Calmette, 67200 Strasbourg, France.
Cancer Radiother. 2022 May;26(3):526-536. doi: 10.1016/j.canrad.2021.08.022. Epub 2021 Oct 30.
Thoracic irradiation requires protection of the heart as an organ at risk of complications. The mean heart dose is the most studied dosimetric parameter in the literature. Recent studies question its relevance in view of the multiplicity of cardiac injuries, the heterogeneity of the cardiac dose distribution and the current technical possibilities to refine cardiac dosimetric protection. The objective of this literature review is to analyze the available scientific data on the impact of the dose received by the cardiac substructures. A search of articles using the PubMed search engine was used to select the most relevant studies. A total of 19 articles were selected according to pre-established criteria to answer the issue. Several studies found significant associations between dosimetric parameters of substructures and clinical cardiological impact. Some proposed dose constraints for substructures.
胸部放疗需要保护心脏这一有并发症风险的器官。平均心脏剂量是文献中研究最多的剂量学参数。鉴于心脏损伤的多样性、心脏剂量分布的异质性以及当前改善心脏剂量学保护的技术可能性，近期研究对其相关性提出了质疑。这篇文献综述的目的是分析关于心脏亚结构所接受剂量影响的现有科学数据。使用PubMed搜索引擎搜索文章以选择最相关的研究。根据预先设定的标准共选择了19篇文章来回答该问题。一些研究发现亚结构的剂量学参数与临床心脏影响之间存在显著关联。一些研究还提出了亚结构的剂量限制。
