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非目标饲料中24种抗菌活性物质的最大交叉污染水平。第5部分:

Maximum levels of cross-contamination for 24 antimicrobial active substances in non-target feed. Part 5: .

作者信息

Koutsoumanis Konstantinos, Allende Ana, Alvarez-Ordóñez Avelino, Bolton Declan, Bover-Cid Sara, Chemaly Marianne, Davies Robert, De Cesare Alessandra, Herman Lieve, Hilbert Friederike, Lindqvist Roland, Nauta Maarten, Ru Giuseppe, Simmons Marion, Skandamis Panagiotis, Suffredini Elisabetta, Andersson Dan I, Bampidis Vasileios, Bengtsson-Palme Johan, Bouchard Damien, Ferran Aude, Kouba Maryline, López Puente Secundino, López-Alonso Marta, Nielsen Søren Saxmose, Pechová Alena, Petkova Mariana, Girault Sebastien, Broglia Alessandro, Guerra Beatriz, Innocenti Matteo Lorenzo, Liébana Ernesto, López-Gálvez Gloria, Manini Paola, Stella Pietro, Peixe Luisa

出版信息

EFSA J. 2021 Oct 26;19(10):e06856. doi: 10.2903/j.efsa.2021.6856. eCollection 2021 Oct.

Abstract

The specific concentrations of lincomycin in non-target feed for food-producing animals, below which there would not be an effect on the emergence of, and/or selection for, resistance in bacteria relevant for human and animal health, as well as the specific antimicrobial concentrations in feed which have an effect in terms of growth promotion/increased yield were assessed by EFSA in collaboration with EMA. Details of the methodology used for this assessment, associated data gaps and uncertainties, are presented in a separate document. To address antimicrobial resistance, the Feed Antimicrobial Resistance Selection Concentration (FARSC) model developed specifically for the assessment was applied. However, due to the lack of data on the parameters required to calculate the FARSC, it was not possible to conclude the assessment until further experimental data become available. To address growth promotion, data from scientific publications obtained from an extensive literature review were used. Levels of lincomycin in feed that showed to have an effect on growth promotion/increased yield were reported. It was recommended to carry out studies to generate the data that are required to fill the gaps which prevented the calculation of the FARSC for lincomycin.

摘要

欧洲食品安全局(EFSA)与欧洲药品管理局(EMA)合作,评估了产食用动物的非目标饲料中林可霉素的特定浓度,低于该浓度对与人类和动物健康相关细菌的耐药性出现和/或选择没有影响,以及评估了饲料中具有促进生长/提高产量作用的特定抗菌药物浓度。用于该评估的方法细节、相关数据缺口和不确定性在一份单独文件中呈现。为解决抗菌药物耐药性问题,应用了专门为该评估开发的饲料抗菌药物耐药性选择浓度(FARSC)模型。然而,由于缺乏计算FARSC所需参数的数据,在获得更多实验数据之前无法完成评估。为解决生长促进问题,使用了通过广泛文献综述从科学出版物中获得的数据。报告了饲料中显示对生长促进/提高产量有影响的林可霉素水平。建议开展研究以生成填补空白所需的数据,这些空白妨碍了林可霉素FARSC的计算。

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