Arakawa T, Satoh H, Fukuda T, Nakamura H, Kobayashi K
Gastroenterology. 1987 Jul;93(1):135-40. doi: 10.1016/0016-5085(87)90325-8.
The amount of prostaglandin E2 in endoscopic biopsy specimens from the mucosa of the gastric corpus and antrum of 10 healthy volunteers and 8 patients with alcoholic cirrhosis (7 of whom had portal hypertension) was measured by radioimmunoassay. The mean prostaglandin E2 level in both corpus and antral mucosa was significantly lower in the cirrhotic patients (p less than 0.025). Release of prostaglandin E2 into the gastric cavity was also significantly less in the cirrhotic patients in the basal state (p less than 0.025) and in that of tetragastrin stimulation (4 micrograms/kg, s.c.; p less than 0.01). There was no significant difference in acid secretion between the two groups of subjects. The histologic findings of biopsy specimens showed no difference in the extent of chronic gastritis between the cirrhotic patients and healthy subjects. Therefore, this deficiency of prostaglandin E2 in the gastric mucosa of cirrhotic patients was not related to acid secretion or chronic gastritis.
采用放射免疫分析法对10名健康志愿者以及8例酒精性肝硬化患者（其中7例有门静脉高压）胃体和胃窦黏膜的内镜活检标本中前列腺素E2的含量进行了测定。肝硬化患者胃体和胃窦黏膜中前列腺素E2的平均水平均显著降低（p<0.025）。在基础状态下，肝硬化患者向胃腔内释放的前列腺素E2也显著减少（p<0.025），在四肽胃泌素刺激状态下（4微克/千克，皮下注射；p<0.01）同样如此。两组受试者的胃酸分泌无显著差异。活检标本的组织学检查结果显示，肝硬化患者与健康受试者在慢性胃炎程度上无差异。因此，肝硬化患者胃黏膜中前列腺素E2的这种缺乏与胃酸分泌或慢性胃炎无关。
