Flotyńska Justyna, Jaz Kamila, Cieluch Aleksandra, Grzelka-Woźniak Agata, Kaczmarek Anita, Pypeć Aleksandra, Ciepłucha Wiktoria, Nowicka Aleksandra, Zozulińska-Ziółkiewicz Dorota, Uruska Aleksandra
Department of Internal Medicine and Diabetology, Raszeja Hospital, Poznan, Poland.
Diabetes Metab Res Rev. 2022 Mar;38(3):e3510. doi: 10.1002/dmrr.3510. Epub 2021 Nov 9.
To investigate whether physical activity is associated with the occurrence of remission in adults with type 1 diabetes.
Ninety nine adult participants with newly diagnosed type 1 diabetes were enroled into a prospective, observational study. The participants were advised to exercise 2-3 times a week with moderate intensity for a one-year period. Physical activity was assessed by a self-administrated questionnaire on every fourth visit. We counted the months in which participants fulfiled a partial-remission criteria: HbA1c < 6.5%, C-peptide > 0.5 ng/ml, and daily dose of insulin <0.3 U/kg/day. We assigned the participants to two groups: MORE EFFORT and LESS EFFORT, depending on the median value of physical activity in the studied population.
The occurrence of the remission achieved statistical significance at 6th month with a greater prevalence in MORE EFFORT group (55% vs. 35% p = 0.047). In multivariate logistic regression analysis for the occurrence of remission at 12th month, physical activity before the diagnosis was the only variable that influences the occurrence of the remission (adjusted odds ratios = 3.32 [95% confidence intervals 1.25-8.80]; p = 0.02).
In adults with newly diagnosed type 1 diabetes physical activity before the diagnosis is associated with higher occurrence of remission.
研究身体活动是否与1型糖尿病成人患者缓解的发生有关。
99名新诊断为1型糖尿病的成年参与者被纳入一项前瞻性观察性研究。建议参与者在一年的时间里每周进行2 - 3次中等强度的锻炼。在每次第四次就诊时通过自我管理问卷评估身体活动情况。我们计算参与者达到部分缓解标准的月份：糖化血红蛋白（HbA1c）< 6.5%、C肽> 0.5 ng/ml以及胰岛素每日剂量< 0.3 U/kg/天。根据研究人群中身体活动的中位数，我们将参与者分为两组：更多努力组和较少努力组。
缓解的发生在第6个月达到统计学显著性，更多努力组的患病率更高（55%对35%，p = 0.047）。在对第12个月缓解发生情况的多因素逻辑回归分析中，诊断前的身体活动是影响缓解发生的唯一变量（调整后的优势比= 3.32 [95%置信区间1.25 - 8.80]；p = 0.02）。
在新诊断的1型糖尿病成人患者中，诊断前的身体活动与更高的缓解发生率相关。
