Mohammadpour Mehrdad, Khorrami-Nejad Masoud, Heirani Mohsen
Translational Ophthalmology Research Center, 48438Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran.
Eur J Ophthalmol. 2023 Jan;33(1):NP42-NP46. doi: 10.1177/11206721211049095. Epub 2021 Nov 3.
to report late visual, refractive, and tomographic findings of a patient with progressive keratoconus (KCN) over 7-year follow-up examinations after treatment with an advanced intrastromal implant known as annular intracorneal inlay (AICI) combined with accelerated corneal cross-linking (ACXL).
Slit-lamp photography of anterior segment, corneal tomography maps, and manifest refractions were recorded.
A 30-year-old female presented with the complaint of gradual decreased visual acuity in recent years that was remarkable in her left eye (LE). After clinical examinations, she underwent AICI implantation plus ACXL on her LE. Seven years later, notable improvements were observed in some visual, refractive, and tomographic parameters. The most obvious change was ascribed to the uncorrected distance visual acuity (UDVA) that was 1.3logMAR and 0.4logMAR, before and 7 years after the operation, respectively. However, the preoperative corrected distance visual acuity (CDVA) improved slightly from 0.3logMAR to 0.22logMAR after 7 years. The values of anterior K-max, mean-K, flat-K, and steep-K were flattened by 1.80 D, 1.10 D, 1.00 D, and 1.30 D, respectively. Most visual, refractive, and tomographic data improved or remained stable after 7 years and no remarkable ocular complication was observed at the end of the 7 year.
AICI implantation plus ACXL could be considered as a safe and effective strategy in halting the KCN progression and improving the visual and tomographic properties of the KCN patients. However, future prospective studies with more participants are needed to evaluate the potential effect of AICI implantation on KCN progression.
报告一名进行性圆锥角膜（KCN）患者在接受一种名为环形角膜基质嵌体（AICI）的先进基质内植入物联合加速角膜交联（ACXL）治疗后7年随访检查中的晚期视力、屈光和断层扫描结果。
记录前段裂隙灯摄影、角膜断层扫描图和明显验光结果。
一名30岁女性主诉近年来视力逐渐下降，左眼（LE）尤为明显。经过临床检查，她的左眼接受了AICI植入加ACXL治疗。7年后，在一些视力、屈光和断层扫描参数方面观察到显著改善。最明显的变化归因于未矫正远视力（UDVA），术前为1.3logMAR，术后7年为0.4logMAR。然而，术前矫正远视力（CDVA）在7年后从0.3logMAR略有提高至0.22logMAR。前表面最大曲率（K-max）、平均曲率（mean-K）、平坦曲率（flat-K）和陡峭曲率（steep-K）的值分别变平了1.80 D、1.10 D、1.00 D和1.30 D。7年后，大多数视力、屈光和断层扫描数据有所改善或保持稳定，在7年结束时未观察到明显的眼部并发症。
AICI植入加ACXL可被视为一种安全有效的策略，用于阻止KCN进展并改善KCN患者的视力和断层扫描特性。然而，需要更多参与者的未来前瞻性研究来评估AICI植入对KCN进展的潜在影响。
