Reproductive Medical Center, Guilin, Guangxi, P.R. China.
Gynecol Endocrinol. 2022 Feb;38(2):116-123. doi: 10.1080/09513590.2021.1998438. Epub 2021 Nov 3.
We aimed to evaluate the effect of luteal phase support (LPS) on pregnancy outcome in natural cycle frozen embryo transfer (NC-FET).
We searched PubMed, Cochrane Library, Embase for related literature from start to February 2020. Relative risk ratio (RR) and 95% confidence intervals (95% CI) in random-effects, fixed-effects models were calculated using Review Manager 5.3.
Totally 9 studies were included in the meta-analysis. The results showed no significant difference could be found regarding chemical pregnancy rate (RR 1.07, 95% CI 0.93-1.22; = 54%) and miscarriage rate (RR 0.92, 95% CI 0.70-1.22; = 0%) between the LPS groups and no LPS groups in NC-FET. LPS groups has increased the rate of clinical pregnancy rate (RR 1.23, 95% CI 1.12-1.34; = 52%) compared with no LPS groups. Subgroup analysis according to trigger administration also showed a significant difference between the two groups.
LPS might improve the clinical pregnancy rate in NC-FET. HCG trigger for ovulating may result in luteal phase deficiency. LPS subsequently improved clinical pregnancy rate and chemical pregnancy rate for patients undergoing HCG trigger and NC-FET.
This meta-analysis was registered at PROSPERO, PROSPERO ID is CRD42020171758.
我们旨在评估黄体期支持（LPS）对自然周期冻融胚胎移植（NC-FET）妊娠结局的影响。
我们检索了 PubMed、Cochrane 图书馆、Embase 从开始到 2020 年 2 月的相关文献。使用 Review Manager 5.3 计算随机效应、固定效应模型中的相对风险比（RR）和 95%置信区间（95%CI）。
共有 9 项研究纳入荟萃分析。结果显示，LPS 组和无 LPS 组在 NC-FET 中的生化妊娠率（RR1.07，95%CI0.93-1.22；=54%）和流产率（RR0.92，95%CI0.70-1.22；=0%）无显著差异。与无 LPS 组相比，LPS 组临床妊娠率（RR1.23，95%CI1.12-1.34；=52%）升高。根据触发药物的亚组分析也显示两组之间存在显著差异。
LPS 可能提高 NC-FET 的临床妊娠率。HCG 触发排卵可能导致黄体期不足。LPS 随后改善了接受 HCG 触发和 NC-FET 的患者的临床妊娠率和生化妊娠率。
本荟萃分析在 PROSPERO 注册，PROSPERO ID 为 CRD42020171758。
