Mauvais-Jarvis P
Hum Reprod. 1987 Feb;2(2):159-62. doi: 10.1093/oxfordjournals.humrep.a136501.
The action of fertility-regulating drugs on the breast is discussed. Compounds such as steroids act directly on breast tissues, whereas others, such as clomiphene or gonadotrophin, act indirectly. There can be differential responses of the alveolar and ductal systems. Tissues of a breast tumour typical of epithelial tissues were analysed for changes in cytosolic and nuclear receptors for oestradiol-17 beta and progesterone following its exposure to these steroids. Effects on cell multiplication and receptor density were identified. The relationship of these findings to benign breast disease and oral contraceptives is discussed.
本文讨论了生育调节药物对乳腺的作用。类固醇等化合物直接作用于乳腺组织，而克罗米芬或促性腺激素等其他药物则间接起作用。乳腺的腺泡和导管系统可能会有不同的反应。分析了一种典型上皮组织的乳腺肿瘤组织在暴露于这些类固醇后，其细胞质和细胞核中雌二醇 - 17β和孕酮受体的变化。确定了对细胞增殖和受体密度的影响。还讨论了这些发现与良性乳腺疾病和口服避孕药的关系。
