采用模块化磺酰腙及衍生底物进行发散的 C-C 键形成大环化反应。
Divergent, C-C Bond Forming Macrocyclizations Using Modular Sulfonylhydrazone and Derived Substrates.
机构信息
Department of Chemistry, Center for Molecular Discovery (BU-CMD), Boston University, Boston, Massachusetts 02215, United States.
出版信息
J Org Chem. 2021 Dec 3;86(23):16485-16510. doi: 10.1021/acs.joc.1c01848. Epub 2021 Nov 3.
Abstract
A divergent approach to C-C bond forming macrocycle construction is described. Modular sulfonylhydrazone and derived pyridotriazole substrates with three key building blocks have been constructed and cyclized to afford diverse macrocyclic frameworks. Broad substrate scope and functional group tolerance have been demonstrated. In addition, site-selective postfunctionalization allowed for further diversification of macrocyclic cores.
摘要
描述了一种形成 C-C 键的大环构筑的发散方法。构建了具有三个关键构建块的模块化磺酰腙和衍生的吡啶并三唑底物，并将其环化以提供各种大环框架。展示了广泛的底物范围和官能团耐受性。此外，选择性的后功能化允许进一步多样化大环核。
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