Tsurumi K, Abe A, Nozaki M, Fujimura H
J Toxicol Sci. 1978 Feb;3(1):1-9. doi: 10.2131/jts.3.1.
The influence of single oral dose of anti-inflammatory, antipyretic and analgesic agents on urinary enzymes was investigated in rats as a indicator of nephrotoxic effect. Urinary LDH activity was significantly elevated by aspirin, ketophenylbutazone, aminopyrine, phenacetin and acetaminophen. These drugs increased also H/M ratio of LDH isoenzymes. Although other test drugs have no effect on LDH in urine phenylbutazone and indomethacin elevated GPT and A1-P, oxyphenbutazone did gamma-GT and anthranilic acid derivatives did Al-P and gamma-GT. Other drugs such as sodium salicylate, ibufenac, ibuprofen, bucolome, aminopropylone, sulfinpyrazone, benzydamine and mepirizole did not significantly influence any enzyme activities measured in urine.
以大鼠为实验对象，研究单次口服抗炎、解热和镇痛药对尿酶的影响，以此作为肾毒性作用的指标。阿司匹林、酮基保泰松、氨基比林、非那西丁和对乙酰氨基酚可使尿乳酸脱氢酶（LDH）活性显著升高。这些药物还增加了LDH同工酶的H/M比值。尽管其他受试药物对尿中LDH无影响，但保泰松和吲哚美辛可使谷丙转氨酶（GPT）和碱性磷酸酶（A1-P）升高，羟基保泰松可使γ-谷氨酰转移酶（gamma-GT）升高，邻氨基苯甲酸衍生物可使A1-P和gamma-GT升高。其他药物如水杨酸钠、异丁苯乙酸、布洛芬、布可隆、氨丙酮、磺吡酮、苄达明和美吡唑对所测尿酶活性均无显著影响。
