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术后疼痛与年龄:一项回顾性队列关联研究。

Postoperative Pain and Age: A Retrospective Cohort Association Study.

机构信息

Pain Clinic, Department of Anesthesiology, University Medical Center Utrecht, Utrecht, The Netherlands.

the Department of Anesthesiology and Intensive Care, University Hospital Jena, Jena, Germany.

出版信息

Anesthesiology. 2021 Dec 1;135(6):1104-1119. doi: 10.1097/ALN.0000000000004000.

Abstract

BACKGROUND

As the population ages, the number of elderly people undergoing surgery increases. Literature on the incidence and intensity of postoperative pain in the elderly is conflicting. This study examines associations between age and pain-related patient reported outcomes and perioperative pain management in a dataset of surgical patients undergoing four common surgeries: spinal surgery, hip or knee replacement, or laparoscopic cholecystectomy. Based on the authors' clinical experience, they hypothesize that pain scores are lower in older patients.

METHODS

In this retrospective cohort, study data were collected between 2010 and 2018 as part of the international PAIN OUT program. Patients filled out the International Pain Outcomes Questionnaire on postoperative day 1.

RESULTS

A total of 11,510 patients from 26 countries, 59% female, with a mean age of 62 yr, underwent one of the aforementioned types of surgery. Large variation was detected within each age group for worst pain, yet for each surgical procedure, mean scores decreased significantly with age (mean Numeric Rating Scale range, 6.3 to 7.3; β = -0.2 per decade; P ≤ 0.001), representing a decrease of 1.3 Numeric Rating Scale points across a lifespan. The interference of pain with activities in bed, sleep, breathing deeply or coughing, nausea, drowsiness, anxiety, helplessness, opioid administration on the ward, and wish for more pain treatment also decreases with age for two or more of the procedures. Across the procedures, patients reported being in severe pain on postoperative day one 26 to 38% of the time, and pain interfered moderately to severely with movement.

CONCLUSIONS

The authors' findings indicate that postoperative pain decreases with increasing age. The change is, however, small and of questionable clinical significance. Additionally, there are still too many patients, at any age, undergoing common surgeries who suffer from moderate to severe pain, which interferes with function, supporting the need for tailoring care to the individual patient.

摘要

背景

随着人口老龄化,接受手术的老年人数量增加。关于老年人术后疼痛发生率和强度的文献存在争议。本研究在接受四种常见手术(脊柱手术、髋关节或膝关节置换术或腹腔镜胆囊切除术)的手术患者数据集检查年龄与疼痛相关的患者报告结果和围手术期疼痛管理之间的关联。基于作者的临床经验,他们假设老年患者的疼痛评分较低。

方法

在这项回顾性队列研究中,研究数据于 2010 年至 2018 年期间作为国际 PAIN OUT 计划的一部分收集。患者在术后第 1 天填写国际疼痛结局问卷。

结果

来自 26 个国家的 11510 名患者,女性占 59%,平均年龄为 62 岁,接受了上述类型的手术之一。每个年龄组内的最差疼痛均存在较大差异,但对于每种手术,平均评分随年龄显著下降(平均数字评分量表范围为 6.3 至 7.3;β=-0.2 每十年;P≤0.001),代表在整个生命周期中疼痛减轻 1.3 个数字评分量表点。疼痛对床上活动、睡眠、深呼吸或咳嗽、恶心、嗜睡、焦虑、无助、病房内阿片类药物管理以及更多疼痛治疗的干扰也随着年龄的增长而在两种或更多种手术中减少。在所有手术中,患者在术后第 1 天报告有 26%至 38%的时间处于严重疼痛中,疼痛对运动有中度至重度干扰。

结论

作者的研究结果表明,术后疼痛随年龄增长而减轻。然而,这种变化很小,临床意义值得怀疑。此外,在任何年龄段,接受常见手术的患者中仍有太多患者遭受中度至重度疼痛,这会影响功能,支持根据患者个体情况定制护理。

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