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Loss of tyrosine catabolic enzyme HPD promotes glutamine anaplerosis through mTOR signaling in liver cancer.

作者信息

Tong Man, Wong Tin-Lok, Zhao Hongzhi, Zheng Yuanyuan, Xie Yu-Nong, Li Cheuk-Hin, Zhou Lei, Che Noélia, Yun Jing-Ping, Man Kwan, Kin-Wah Lee Terence, Cai Zongwei, Ma Stephanie

出版信息

Cell Rep. 2021 Nov 2;37(5):109976. doi: 10.1016/j.celrep.2021.109976.

DOI:10.1016/j.celrep.2021.109976
PMID:34731599
Abstract
摘要

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Loss of tyrosine catabolic enzyme HPD promotes glutamine anaplerosis through mTOR signaling in liver cancer.酪氨酸分解酶 HPD 的缺失通过 mTOR 信号促进肝癌中的谷氨酰胺生酮作用。
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